| IED ID | IndEnz0011000466 |
| Enzyme Type ID | glucanase000466 |
| Protein Name |
Sucrose non-fermenting protein kinase 1 EC 2.7.11.1 |
| Gene Name | SNF1 g3696 |
| Organism | Fusarium virguliforme |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta sordariomyceta Sordariomycetes Hypocreomycetidae Hypocreales Nectriaceae Fusarium Fusarium solani species complex Fusarium virguliforme |
| Enzyme Sequence | MAPRGFEDEELTISLSSSHVRRPQQQQPPPPTQQQHAHQPGSRPADAPLKERIKTEQRIGAYKVLRTLGEGSFGKVKLAIHNGTGQQVALKIIARKKLISRDMAGRVEREIEYLQLLRHPHIIKLYTVIKTPNEIIMVLEYAGGELFDYIVQHGRMKEAEARRFFQQMLCAVEYCHRHKIVHRDLKPENLLLDENLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVIGGKLYAGPEVDVWSCGVILYVLLVGRLPFDDEHIPSLFAKIAKGTYSIPQWMPLGAANLIKKMLVVNPVHRATIEDIRADPWFTTELPVYLQLPVEEFFNTGVDPNKAIQKNDIAPNAPEKVQERLHNEVTEKISKTMGYGKNDVEEALQASEPSAIKDAYMIVRENKMMQVNQHPEALLEPEGSSPMLSMSSARSATSTTTTTAPRPYVSKVGILPSSLPAYHKDYVEREKAGSVNNSPPQVLINDELPVTRTDAEKEETSRRLRPHSRSQLRLDEANTRPQGMTPINPPKKTKPVRWQFGIRSRNSPWEALLCIHKALHKLGATYIPDEDYESRHAEERAEASGNGSFADSYDGSRGSTTSIDPMKRYRLPADPWHINVRWDTSAIKKKLQGSADTPDKRQAHEPFVALHLDIQIYEMEHGVYLVDFKCSGYETATGRLLEEKEVTSPFPFLDMAAKLIMQLAEAD |
| Enzyme Length | 698 |
| Uniprot Accession Number | P0DP15 |
| Absorption | |
| Active Site | ACT_SITE 184; /note=Proton acceptor; /evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Activity Regulation | |
| Binding Site | BINDING 91; /note=ATP; /evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000250|UniProtKB:P06782}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000250|UniProtKB:P06782}; |
| DNA Binding | |
| EC Number | 2.7.11.1 |
| Enzyme Function | FUNCTION: Catalytic subunit of the AMP-activated protein kinase complex also known as the SNF1 kinase complex (Snf1c), a central regulator of cellular energy homeostasis, which, in response to a fall in intracellular ATP levels, activates energy-producing pathways and inhibits energy-consuming processes (By similarity). The complex phosphorylates histone H3 to form H3S10ph, which promotes H3K14ac formation, leading to transcriptional activation through TBP recruitment to the promoters (By similarity). Activates the expression of the galactose oxidase (GOA) gene and of several cell wall-degrading enzymes (CWDEs) such as pectate lyase, xylanase and glucanase (PubMed:28132080). Plays an important role in sudden death syndrome (SDS) by controlling the colonization of the infected roots (PubMed:28132080). {ECO:0000250|UniProtKB:P06782, ECO:0000269|PubMed:28132080}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | NP_BIND 68..76; /note=ATP; /evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Features | Active site (1); Binding site (1); Chain (1); Compositional bias (3); Domain (2); Nucleotide binding (1); Region (5) |
| Keywords | ATP-binding;Carbohydrate metabolism;Cytoplasm;Kinase;Nucleotide-binding;Nucleus;Serine/threonine-protein kinase;Transferase;Virulence |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P06782}. Nucleus {ECO:0000250|UniProtKB:P06782}. Note=Nuclear translocation occurs under nitrogen and glucose starvation conditions (By similarity). {ECO:0000250|UniProtKB:P06782}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 78,591 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:17989; RHEA:46608 |
| Cross Reference Brenda |