| IED ID | IndEnz0013000007 |
| Enzyme Type ID | keratinase000007 |
| Protein Name |
Neutral metalloproteinase EC 3.4.24.- |
| Gene Name | |
| Organism | Geobacillus stearothermophilus (Bacillus stearothermophilus) |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Bacillales Bacillaceae Geobacillus Geobacillus stearothermophilus (Bacillus stearothermophilus) |
| Enzyme Sequence | MNKRAMLGAIGLAFGLMAWPLGASAKERSMVWNEQWKTPSFVSGPLLKGEDAPEELVYRYLDQEKNTFQLGGQARERLSLIGKQTDELGHTVMRFEQRYHGIPVYGAVLVAHVNDGELSSLSGTLIPNLDKRTLKTEAAISVQQAEMIAKQDVADAVTKERPAAEEGKPTRLVIYPDGETPRLAYEVNVRFLTPVPGNWIYMIDAADGNVLNKWNQMDEAKPGGGQSVAGASTVGVGRGVLGDQKYINTTYSSYYGYYYLQDNTRGSGIFTYDGRNRTVLPGSLWADGDNQFFASYDAAAVDAHYYAGVVYDYYKNVHGRLSYDGSNAAIHSTVHYGRGYNNAFWNGSQMVYGDGDGQTFLPFSGGIDVVGHELTHAVTDYTAGLVYQNESGAINEAMSDIFGTLVEFYANRNPDWEIGEDIYTPGIAGDALRSMSDPAKYGDPDHYSKRYTGTQDNGGVHTNSGIINKAAYLLSQGGVHYGVSVTGIGRDKMGKIFYRALVYYLTPTSNFSQLRAACVQAAADLYGSTSQEVNSVKQAFNAVGVY |
| Enzyme Length | 546 |
| Uniprot Accession Number | A0A0B4ZU77 |
| Absorption | |
| Active Site | ACT_SITE 373; /evidence=ECO:0000256|PIRSR:PIRSR623612-1; ACT_SITE 461; /note=Proton donor; /evidence=ECO:0000256|PIRSR:PIRSR623612-1 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Extracellular zinc metalloprotease. {ECO:0000256|RuleBase:RU366073}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Domain (4); Signal peptide (1) |
| Keywords | Calcium;Hydrolase;Metalloprotease;Protease;Secreted;Signal;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU366073}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..25; /evidence=ECO:0000256|RuleBase:RU366073 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 59,667 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |