Detail Information for IndEnz0013000008
IED ID IndEnz0013000008
Enzyme Type ID keratinase000008
Protein Name Neutral metalloproteinase
EC 3.4.24.-
Fragment
Gene Name
Organism Pseudomonas aeruginosa
Taxonomic Lineage cellular organisms Bacteria Proteobacteria Gammaproteobacteria Pseudomonadales Pseudomonadaceae Pseudomonas Pseudomonas aeruginosa group Pseudomonas aeruginosa
Enzyme Sequence ADLIDVSKLPSKAAQGAPGPVTLQAAVGAGGADELKAIRSTTLPNGKQVTRYEQFHNGVRVVGEAITEVKGPGKSVAAQRSGHFVANIAADLPGSTTAAVSAEQVLAQAKSLKAQGRKTENDKVELVIRLGENNIAQLVYNVSYLIPGEGLSRPHFVIDAKTGEVLDQWEGLAHAEAGGPGGNQKIGKYTYGSDYGPLIVNDRCEMDDGNVITVDMNSSTDDSKTTPFRFACPTNTYKQVNGAYSPLNDAHFFGGVVFKLYRDWFGTSPLTHKLYMKVHYGRSVENAYWDGTAMLFGDGATMFYPLVSLDVAAHEVSHGFTEQNSGLIYRGQSGGMNEAFSDMAGEAAEFYMRGKNDFLIGYDIKKGSGALRYMDQPSRDGRSIDNASQYYNGIDVHHSSGVYNRAFYLLANSPGWDTRKAFEVFVDANRYYWTATSNYNSGACGVIRSAQNRNYSAADVTRAFSTVGVTCPSAL
Enzyme Length 475
Uniprot Accession Number E3ULB4
Absorption
Active Site ACT_SITE 315; /evidence=ECO:0000256|PIRSR:PIRSR623612-1; ACT_SITE 397; /note=Proton donor; /evidence=ECO:0000256|PIRSR:PIRSR623612-1
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.24.-
Enzyme Function FUNCTION: Extracellular zinc metalloprotease. {ECO:0000256|RuleBase:RU366073}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (2); Disulfide bond (2); Domain (4); Non-terminal residue (1)
Keywords 3D-structure;Hydrolase;Metalloprotease;Protease;Secreted;Signal;Zinc
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU366073}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D X-ray crystallography (1)
Cross Reference PDB 7AJR;
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 51,295
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda