| IED ID |
IndEnz0015000118 |
| Enzyme Type ID |
laccase000118 |
| Protein Name |
Transcriptional regulator CRZ1
|
| Gene Name |
CRZ1 SP1 CNAG_00156 |
| Organism |
Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Fungi
Dikarya
Basidiomycota
Agaricomycotina
Tremellomycetes
Tremellales (jelly fungi)
Cryptococcaceae
Cryptococcus
Cryptococcus neoformans species complex
Cryptococcus neoformans (Filobasidiella neoformans)
Cryptococcus neoformans var. grubii (Filobasidiella neoformans var. grubii)
Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
|
| Enzyme Sequence |
MADPASPPSFDAIFAQQPVRRSSSTSTSSFANYTYSALQQHQQFNSDAPLVDEPQSLSEQARKQQRDPSKDGNNKRYLDMMSGLADGYGVINGRRQESLRKESLPFNPQEDSTLIATAPKRGERNGLGRNGYSSPIGDIMFGPEQTIPNQPQQPSQQPPWGEGRMSEQSVHYASVQQPQYSSFQSSGPGAGSAGIDYLPRGTTSSMNDSMLSSQISPYLNHDVASEGQPPQQQQQQQQQQQGEWGQEFIGVEQQQQYAQGEGQSNGMEDMLTMGDESPFESELQRVISNTSHPSQYPSRTSSPFPQQSQSNMVPASTVNQTRTESFPASRSPSPFAPQQASQTEASNHVVSTPSMGQPTYPRASSSPRTNPNSPFFNKPQSPPALIIPNSPVLPNIVTQSTSNNHSKGLNQPHTRHASNGAGGLFPPSNPALEHLTGMAGISPIAPNADGPMICIQPSTPISGLKEGRGLFDAALRRAGAARGAQRQGPQGQGESQEDRRQDGFNVPSPQSHPLPRTLSSDQVNQGVEMQGMDFAAQMQSYEQQGWANDTLRIAGPSRPRAKSDSIIPSPTADSFDRQAFLAFIGAGNAQPPPPNVEMQPGYVDVSEQWRNTVSAWKAGLGEGELNSQPTLDPRLLPGRESNEAVYQQLLMQQQTGQMPRLDPDQLHQLTQLEGQRARFSLNTNIAPPKYEPGEISPTSMVFYQSMGLYPHAAPELSGTVSAPWSQTAFGQVPGPGPVGHPATAGPAQQHFLTPTLSHATVRRRSFGGGEHPAMGAGTPGYGMEFSSPFAGKSVGQIRGVNMGHRRAARSEDFGRGGTGWGVGAGGSTAEFLQSITGDDGSLLPPSNRGHAMSHSRHSSTSSIRSASPALSISSQGSSFSHHSPRMDMPDSIYPGHPIIAPATPLQVSGLYEEQQTPARVAKMKVTSVATEVASTSRRTNSGIFKCPVPGCGSTFTRHFNLKGHLRSHNDERPFKCLYEGCPKAIVGFARQHDCKRHMLLHEGLRLFECEGCGKKFARLDALTRHHKSEQGQECAITHPLPTNFDGSPMSESQYKTYKGIKSTPEGSGRRLSSTASGSGSGKRRSKKSETSEED |
| Enzyme Length |
1094 |
| Uniprot Accession Number |
J9VE33 |
| Absorption |
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| Active Site |
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| Activity Regulation |
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| Binding Site |
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| Calcium Binding |
|
| catalytic Activity |
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| DNA Binding |
|
| EC Number |
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| Enzyme Function |
FUNCTION: DNA-binding transcriptional activator that interacts with calcineurin-dependent response element (CDRE) promoters (PubMed:28376087). Activates expression of genes required to maintain cell wall integrity during stress (PubMed:23251520, PubMed:28376087). Activates expression of genes required for transepithelial migration through the host blood-brain barrier (PubMed:29113016). Required for adaptation to host temperature during infection (PubMed:28376087). {ECO:0000269|PubMed:23251520, ECO:0000269|PubMed:28376087, ECO:0000303|PubMed:28376087, ECO:0000303|PubMed:29113016}. |
| Temperature Dependency |
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| PH Dependency |
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| Pathway |
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| nucleotide Binding |
|
| Features |
Chain (1); Compositional bias (9); Modified residue (7); Mutagenesis (3); Region (6); Zinc finger (2) |
| Keywords |
Activator;Cytoplasm;DNA-binding;Metal-binding;Nucleus;Phosphoprotein;Repeat;Transcription;Transcription regulation;Virulence;Zinc;Zinc-finger |
| Interact With |
|
| Induction |
INDUCTION: Induced during glucose starvation. {ECO:0000269|PubMed:21487010}. |
| Subcellular Location |
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:23251520, ECO:0000269|PubMed:27611567, ECO:0000269|PubMed:28376087, ECO:0000269|PubMed:28898238, ECO:0000269|PubMed:31266771}. Nucleus {ECO:0000269|PubMed:21487010, ECO:0000269|PubMed:23251520, ECO:0000269|PubMed:24520056, ECO:0000269|PubMed:27611567, ECO:0000269|PubMed:28376087, ECO:0000269|PubMed:28898238, ECO:0000269|PubMed:31266771}. Note=Localizes to the nucleus during calcium signaling, cell wall and heat stress (PubMed:21487010, PubMed:23251520, PubMed:24520056, PubMed:27611567, PubMed:28376087, PubMed:28898238, PubMed:31266771). Localizes to the nucleus following dephosphorylation by CNA1 (calcineurin) (PubMed:27611567). Localizes to the nucleus during growth on glucosamine carbon source (PubMed:28898238). Localizes to the cytosol during vegetative growth and osmotic stress (PubMed:23251520, PubMed:28376087, PubMed:28898238). {ECO:0000269|PubMed:21487010, ECO:0000269|PubMed:23251520, ECO:0000269|PubMed:24520056, ECO:0000269|PubMed:27611567, ECO:0000269|PubMed:28376087, ECO:0000269|PubMed:28898238, ECO:0000269|PubMed:31266771}. |
| Modified Residue |
MOD_RES 103; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:27611567; MOD_RES 288; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:27611567; MOD_RES 329; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:27611567; MOD_RES 508; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:27611567; MOD_RES 569; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:27611567; MOD_RES 765; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:27611567; MOD_RES 810; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:27611567 |
| Post Translational Modification |
PTM: Phosphorylated (PubMed:21487010, PubMed:27611567). Dephosphorylated by calcineurin (CNA1) which promotes nuclear localization (PubMed:27611567). {ECO:0000269|PubMed:21487010, ECO:0000269|PubMed:27611567}. |
| Signal Peptide |
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| Structure 3D |
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| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
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| Gene Encoded By |
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| Mass |
117,964 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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