| IED ID | IndEnz0016000017 |
| Enzyme Type ID | tyrosinase000017 |
| Protein Name |
Tyrosinase EC 1.14.18.1 Monophenol monooxygenase |
| Gene Name | melC2 mel |
| Organism | Streptomyces glaucescens |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Actinobacteria Actinomycetia (high G+C Gram-positive bacteria) Streptomycetales Streptomycetaceae Streptomyces Streptomyces glaucescens |
| Enzyme Sequence | MTVRKNQATLTADEKRRFVAAVLELKRSGRYDEFVTTHNAFIIGDTDAGERTGHRSPSFLPWHRRYLLEFERALQSVDASVALPYWDWSADRTARASLWAPDFLGGTGRSLDGRVMDGPFAASAGNWPINVRVDGRAYLRRSLGTAVRELPTRAEVESVLGMATYDTAPWNSASDGFRNHLEGWRGVNLHNRVHVWVGGQMATGMSPNDPVFWLHHAYVDKLWAEWQRRHPGSGYLPAAGTPDVVDLNDRMKPWNDTSPADLLDHTAHYTFDTD |
| Enzyme Length | 274 |
| Uniprot Accession Number | P06845 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone; Xref=Rhea:RHEA:34287, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57504, ChEBI:CHEBI:57924; EC=1.14.18.1; CATALYTIC ACTIVITY: Reaction=L-tyrosine + O2 = H2O + L-dopaquinone; Xref=Rhea:RHEA:18117, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57924, ChEBI:CHEBI:58315; EC=1.14.18.1; |
| DNA Binding | |
| EC Number | 1.14.18.1 |
| Enzyme Function | FUNCTION: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Initiator methionine (1); Metal binding (6); Mutagenesis (7); Sequence conflict (1) |
| Keywords | Copper;Direct protein sequencing;Melanin biosynthesis;Metal-binding;Monooxygenase;Oxidoreductase |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 30,874 |
| Kinetics | |
| Metal Binding | METAL 38; /note="Copper A"; /evidence="ECO:0000269|PubMed:1901488, ECO:0000269|PubMed:2846043"; METAL 54; /note="Copper A"; /evidence="ECO:0000269|PubMed:1901488, ECO:0000269|PubMed:2846043"; METAL 63; /note="Copper A"; /evidence="ECO:0000269|PubMed:1901488, ECO:0000269|PubMed:2846043"; METAL 190; /note="Copper B"; /evidence="ECO:0000269|PubMed:1901488, ECO:0000269|PubMed:2846043"; METAL 194; /note="Copper B"; /evidence="ECO:0000269|PubMed:1901488, ECO:0000269|PubMed:2846043"; METAL 216; /note="Copper B"; /evidence="ECO:0000269|PubMed:1901488, ECO:0000269|PubMed:2846043" |
| Rhea ID | RHEA:34287; RHEA:18117 |
| Cross Reference Brenda |