Detail Information for IndEnz0016000026
IED ID IndEnz0016000026
Enzyme Type ID tyrosinase000026
Protein Name Tyrosinase
EC 1.14.18.1
Monophenol monooxygenase
Gene Name tyr tyro
Organism Oryzias latipes (Japanese rice fish) (Japanese killifish)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Actinopterygii Actinopteri Neopterygii Teleostei Osteoglossocephalai Clupeocephala Euteleosteomorpha Neoteleostei Eurypterygia Ctenosquamata Acanthomorphata Euacanthomorphacea Percomorphaceae Ovalentaria Atherinomorphae Beloniformes (medakas needlefish and others) Adrianichthyoidei Adrianichthyidae Oryziinae (medakas) Oryzias Oryzias latipes (Japanese rice fish) (Japanese killifish)
Enzyme Sequence MKSLFLSAVLLQFFETCWSQFPRPCANSEGLRTKECCPVWSGDGSPCGALSGRGFCADVSVSDEPNGPQYPHSGIDDRERWPLAFFNRTCRCAGNYGGFNCGECRFGYWGSNCAEYRESVRRNIMSMSTTEQQKFISYLNLAKNTINPDYVITTGTRAEMGENGESPMFSDINTYDLFVWIHYYVSRDTFLGGPGNVWRDIDFAHESAAFLPWHRVYLLHWEQEIRKITGDFNFTIPYWDWRDAQSCEVCTDNLMGGRNALNPNLISPASVFSSWKVICTQQEEYNNQEALCNATAEGPLLRNPGNHDPNRVPRIPTTADVEFTISLPEYETGSMDRFANNSFRNVLEGFASPETGMAVQGQSTMHNALHVFMNGSMSSVQGSANDPIFLLHHAFIDSIFERWLRTHQPPRSIYPRTNAPIGHNDGYYMVPFLPLYRNGDYLLSNKALGYEYAYLLDPGQRFVQEFLTPYLQQAQQIWQWLLGAGILGALIATIVAAVIVFARRKRRRNQKRKRAPSFGERQPLLQSSSEEGSSSYQTTL
Enzyme Length 540
Uniprot Accession Number P55025
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone; Xref=Rhea:RHEA:34287, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57504, ChEBI:CHEBI:57924; EC=1.14.18.1; CATALYTIC ACTIVITY: Reaction=L-tyrosine + O2 = H2O + L-dopaquinone; Xref=Rhea:RHEA:18117, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57924, ChEBI:CHEBI:58315; EC=1.14.18.1;
DNA Binding
EC Number 1.14.18.1
Enzyme Function FUNCTION: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Compositional bias (1); Glycosylation (5); Metal binding (6); Region (1); Signal peptide (1); Topological domain (2); Transmembrane (1)
Keywords Copper;Glycoprotein;Melanin biosynthesis;Membrane;Metal-binding;Monooxygenase;Oxidoreductase;Reference proteome;Signal;Transmembrane;Transmembrane helix
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Melanosome membrane; Single-pass type I membrane protein.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..19; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 61,254
Kinetics
Metal Binding METAL 182; /note=Copper A; /evidence=ECO:0000250|UniProtKB:Q9ZP19; METAL 205; /note=Copper A; /evidence=ECO:0000250|UniProtKB:Q9ZP19; METAL 214; /note=Copper A; /evidence=ECO:0000250|UniProtKB:Q9ZP19; METAL 366; /note=Copper B; /evidence=ECO:0000250|UniProtKB:Q9ZP19; METAL 370; /note=Copper B; /evidence=ECO:0000250|UniProtKB:Q9ZP19; METAL 393; /note=Copper B; /evidence=ECO:0000250|UniProtKB:Q9ZP19
Rhea ID RHEA:34287; RHEA:18117
Cross Reference Brenda