Detail Information for IndEnz0016000033
IED ID IndEnz0016000033
Enzyme Type ID tyrosinase000033
Protein Name P protein
Melanocyte-specific transporter protein
Pink-eyed dilution protein
Gene Name Oca2 P
Organism Mus musculus (Mouse)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse)
Enzyme Sequence MRLENKDIRLASAVLEVELHQTSALSVPTCPDPGRLLTVKPATSNYKLGQADPCIPYAGEAAGKSVCVPEHTEFGSFLVKGSSSLKDLSFKEDTPLLWNSSQKKRSQLMPVHHPEFIATEGSWENGLTAWEQKCMLGKEVADLSALASSEKRDLAGSVHLRAQVSKLGCCVRWIKITGLFVFVVLCSILFSLYPDQGKFWQLLAVSPLENYSVNLSGHADSMILQLDLAGALMAGGPSGSGKEEHVVVVVTQTDAAGNRRRRPQQLTYNWTVLLNPRSEHVVVSRTFEIVSREAVSISIQASLQQTRLVPLLLAHQFLGASVEAQVASAVAILAGVYTLIIFEIVHRTLAAMLGALAALAALAVVGDRPSLTHVVEWIDFETLALLFGMMILVAVFSETGFFDYCAVKAYQLSRGRVWAMIFMLCLMAAILSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGFTAHMFLGICLVLLVSFPLLRLLYWNKKLYNKEPSEIVELKHEIHVWRLTAQRISPASREETAVRGLLLEKVLALEHLLAQRLHTFHRQISQEDKNWETNIQELQRKHRISDRSLLVKCLTVLGFVISMFFLNSFVPGIHLDLGWIAILGAIWLLILADIHDFEIILHRVEWATLLFFAALFVLMEALTHLHLVEYVGEQTALLIKMVPEDQRFAAAIVLIVWVSALASSLIDNIPFTATMIPVLLNLSQDPEISLPALPLMYALALGACLGGNGTLIGASTNVVCAGIAEKHGYGFSFMEFFRLGFPVMLMSCTIGMCYLLIAHIVVGWN
Enzyme Length 833
Uniprot Accession Number Q62052
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the postranslational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. It can modulate intracellular glutathione metabolism. {ECO:0000269|PubMed:11310796}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Glycosylation (3); Topological domain (13); Transmembrane (12)
Keywords Albinism;Glycoprotein;Membrane;Reference proteome;Transmembrane;Transmembrane helix;Transport
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Melanosome membrane {ECO:0000269|PubMed:7991586}; Multi-pass membrane protein {ECO:0000269|PubMed:7991586}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 10068480; 102659; 10441737; 10517996; 1054503; 10590213; 10590232; 1063212; 10760285; 10903848; 10946246; 10998130; 10998131; 11074018; 11095635; 11106796; 11254699; 11285201; 11756244; 11857469; 12028586; 12064459; 1225761; 12354157; 12466851; 12606284; 12644183; 12856284; 1303276; 1303278; 1347469; 1378547; 13877379; 13914573; 13943454; 1409429; 14402638; 14487977; 14500365; 14530442; 14706343; 1495987; 15051828; 15620220; 16075369; 1611213; 16124007; 16185282; 16202662; 162962; 16602821; 1673574; 17245945; 17246029; 17246039; 17246054; 17246260; 17247190; 17247200; 17247280; 17247308; 17247639; 17247933; 17248484; 17516930; 17584907; 17629744; 18117146; 18177347; 18639560; 18890162; 19427509; 1970795; 1982431; 19887611; 21118969; 21232027; 21267068; 2137109; 21392365; 21677750; 21709021; 22677273; 22718909; 23106556; 2344351; 23609791; 2364541; 2379821; 23962237; 24118800; 25656818; 25736709; 25739360; 25917818; 26971330; 2744450; 28009282; 2813427; 29475039; 29617656; 3319884; 3897441; 4397868; 4435358; 447675; 4634048; 5094803; 5565073; 5833112; 5902512; 6088946; 6101098; 621381; 6279728; 6327825; 6663229; 7117836; 7295293; 7317942; 7526177; 7581464; 7601462; 7604002; 7665913; 7683307; 7698755; 7761348; 7774555; 7849740; 7889410; 7894156; 7963676; 7985029; 8001787; 8095339; 8146195; 8224069; 8278937; 8288260; 8389469; 8392662; 8419934; 8421497; 8499656; 8575552; 8601493; 8601494; 863229; 8661705; 8661718; 8672132; 872192; 8769098; 8783939; 8789196; 8789201; 8812411; 9060416; 9100310; 9108119; 9114032; 9195990; 9330366; 9521852; 9548375; 9564894; 9602068; 9635590; 9656467; 9670976; 9682826; 9689098; 9922399;
Motif
Gene Encoded By
Mass 91,869
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda