| IED ID | IndEnz0016000033 |
| Enzyme Type ID | tyrosinase000033 |
| Protein Name |
P protein Melanocyte-specific transporter protein Pink-eyed dilution protein |
| Gene Name | Oca2 P |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MRLENKDIRLASAVLEVELHQTSALSVPTCPDPGRLLTVKPATSNYKLGQADPCIPYAGEAAGKSVCVPEHTEFGSFLVKGSSSLKDLSFKEDTPLLWNSSQKKRSQLMPVHHPEFIATEGSWENGLTAWEQKCMLGKEVADLSALASSEKRDLAGSVHLRAQVSKLGCCVRWIKITGLFVFVVLCSILFSLYPDQGKFWQLLAVSPLENYSVNLSGHADSMILQLDLAGALMAGGPSGSGKEEHVVVVVTQTDAAGNRRRRPQQLTYNWTVLLNPRSEHVVVSRTFEIVSREAVSISIQASLQQTRLVPLLLAHQFLGASVEAQVASAVAILAGVYTLIIFEIVHRTLAAMLGALAALAALAVVGDRPSLTHVVEWIDFETLALLFGMMILVAVFSETGFFDYCAVKAYQLSRGRVWAMIFMLCLMAAILSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGFTAHMFLGICLVLLVSFPLLRLLYWNKKLYNKEPSEIVELKHEIHVWRLTAQRISPASREETAVRGLLLEKVLALEHLLAQRLHTFHRQISQEDKNWETNIQELQRKHRISDRSLLVKCLTVLGFVISMFFLNSFVPGIHLDLGWIAILGAIWLLILADIHDFEIILHRVEWATLLFFAALFVLMEALTHLHLVEYVGEQTALLIKMVPEDQRFAAAIVLIVWVSALASSLIDNIPFTATMIPVLLNLSQDPEISLPALPLMYALALGACLGGNGTLIGASTNVVCAGIAEKHGYGFSFMEFFRLGFPVMLMSCTIGMCYLLIAHIVVGWN |
| Enzyme Length | 833 |
| Uniprot Accession Number | Q62052 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the postranslational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. It can modulate intracellular glutathione metabolism. {ECO:0000269|PubMed:11310796}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Glycosylation (3); Topological domain (13); Transmembrane (12) |
| Keywords | Albinism;Glycoprotein;Membrane;Reference proteome;Transmembrane;Transmembrane helix;Transport |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Melanosome membrane {ECO:0000269|PubMed:7991586}; Multi-pass membrane protein {ECO:0000269|PubMed:7991586}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10068480; 102659; 10441737; 10517996; 1054503; 10590213; 10590232; 1063212; 10760285; 10903848; 10946246; 10998130; 10998131; 11074018; 11095635; 11106796; 11254699; 11285201; 11756244; 11857469; 12028586; 12064459; 1225761; 12354157; 12466851; 12606284; 12644183; 12856284; 1303276; 1303278; 1347469; 1378547; 13877379; 13914573; 13943454; 1409429; 14402638; 14487977; 14500365; 14530442; 14706343; 1495987; 15051828; 15620220; 16075369; 1611213; 16124007; 16185282; 16202662; 162962; 16602821; 1673574; 17245945; 17246029; 17246039; 17246054; 17246260; 17247190; 17247200; 17247280; 17247308; 17247639; 17247933; 17248484; 17516930; 17584907; 17629744; 18117146; 18177347; 18639560; 18890162; 19427509; 1970795; 1982431; 19887611; 21118969; 21232027; 21267068; 2137109; 21392365; 21677750; 21709021; 22677273; 22718909; 23106556; 2344351; 23609791; 2364541; 2379821; 23962237; 24118800; 25656818; 25736709; 25739360; 25917818; 26971330; 2744450; 28009282; 2813427; 29475039; 29617656; 3319884; 3897441; 4397868; 4435358; 447675; 4634048; 5094803; 5565073; 5833112; 5902512; 6088946; 6101098; 621381; 6279728; 6327825; 6663229; 7117836; 7295293; 7317942; 7526177; 7581464; 7601462; 7604002; 7665913; 7683307; 7698755; 7761348; 7774555; 7849740; 7889410; 7894156; 7963676; 7985029; 8001787; 8095339; 8146195; 8224069; 8278937; 8288260; 8389469; 8392662; 8419934; 8421497; 8499656; 8575552; 8601493; 8601494; 863229; 8661705; 8661718; 8672132; 872192; 8769098; 8783939; 8789196; 8789201; 8812411; 9060416; 9100310; 9108119; 9114032; 9195990; 9330366; 9521852; 9548375; 9564894; 9602068; 9635590; 9656467; 9670976; 9682826; 9689098; 9922399; |
| Motif | |
| Gene Encoded By | |
| Mass | 91,869 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |