Detail Information for IndEnz0016000038
IED ID IndEnz0016000038
Enzyme Type ID tyrosinase000038
Protein Name Ras-related protein Rab-38
Gene Name Rab38
Organism Mus musculus (Mouse)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse)
Enzyme Sequence MQTPHKEHLYKLLVIGDLGVGKTSIIKRYVHQNFSSHYRATIGVDFALKVLHWDPETVVRLQLWDIAGQERFGNMTRVYYREAMGAFIVFDVTRPATFEAVAKWKNDLDSKLTLPNGKPVSVVLLANKCDQGKDVLMNNGLKMDQFCKEHGFVGWFETSAKENINIDEASRCLVKHILANECDLLESIEPDIVKPHLTSPKVVSCSGCAKS
Enzyme Length 211
Uniprot Accession Number Q8QZZ8
Absorption
Active Site
Activity Regulation ACTIVITY REGULATION: Regulated by a guanine nucleotide-exchange factor (GEF) and a GTPase-activating protein (GAP) and alternates between an inactive GDP-bound and an active GTP-bound form. The BLOC-3 complex composed of HPS1 and HPS4 acts as its GEF, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. SGSM2 acts as its GAP and inactivates it by stimulating its GTPase activity (PubMed:26620560). {ECO:0000269|PubMed:26620560}.
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium (By similarity). May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (PubMed:21187289). Plays an important role in the control of melanin production and melanosome biogenesis (By similarity). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (PubMed:26620560). {ECO:0000250|UniProtKB:P57729, ECO:0000269|PubMed:21187289, ECO:0000269|PubMed:26620560}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding NP_BIND 16..23; /note=GTP; /evidence=ECO:0000250; NP_BIND 65..69; /note=GTP; /evidence=ECO:0000250; NP_BIND 127..130; /note=GTP; /evidence=ECO:0000250
Features Chain (1); Lipidation (2); Motif (1); Mutagenesis (2); Natural variant (1); Nucleotide binding (3); Sequence conflict (3)
Keywords Albinism;Cell membrane;Cytoplasmic vesicle;Disease variant;GTP-binding;Lipoprotein;Membrane;Nucleotide-binding;Palmitate;Prenylation;Protein transport;Reference proteome;Transport
Interact With Q3UMR0
Induction
Subcellular Location SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:P57729}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Melanosome {ECO:0000269|PubMed:26620560}. Melanosome membrane {ECO:0000250|UniProtKB:P57729}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization. {ECO:0000250|UniProtKB:P57729}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 10725249; 11217851; 12466851; 17043139; 17671165; 17724166; 1835927; 18477474; 18715234; 18832574; 19403694; 19493314; 21267068; 22660928; 22985540; 23426636; 24127780; 25360523; 25685662; 26876013; 28438206; 31399401; 8422502; 9585243;
Motif MOTIF 38..46; /note=Effector region; /evidence=ECO:0000250
Gene Encoded By
Mass 23,776
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda