| IED ID | IndEnz0016000104 |
| Enzyme Type ID | tyrosinase000104 |
| Protein Name |
Cadherin-3 Placental cadherin P-cadherin |
| Gene Name | Cdh3 Cdhp |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MELLSGPHAFLLLLLQVCWLRSVVSEPYRAGFIGEAGVTLEVEGTDLEPSQVLGKVALAGQGMHHADNGDIIMLTRGTVQGGKDAMHSPPTRILRRRKREWVMPPIFVPENGKGPFPQRLNQLKSNKDRGTKIFYSITGPGADSPPEGVFTIEKESGWLLLHMPLDREKIVKYELYGHAVSENGASVEEPMNISIIVTDQNDNKPKFTQDTFRGSVLEGVMPGTSVMQVTATDEDDAVNTYNGVVAYSIHSQEPKEPHDLMFTIHKSTGTISVISSGLDREKVPEYRLTVQATDMDGEGSTTTAEAVVQILDANDNAPEFEPQKYEAWVPENEVGHEVQRLTVTDLDVPNSPAWRATYHIVGGDDGDHFTITTHPETNQGVLTTKKGLDFEAQDQHTLYVEVTNEAPFAVKLPTATATVVVHVKDVNEAPVFVPPSKVIEAQEGISIGELVCIYTAQDPDKEDQKISYTISRDPANWLAVDPDSGQITAAGILDREDEQFVKNNVYEVMVLATDSGNPPTTGTGTLLLTLTDINDHGPIPEPRQIIICNQSPVPQVLNITDKDLSPNSSPFQAQLTHDSDIYWMAEVSEKGDTVALSLKKFLKQDTYDLHLSLSDHGNREQLTMIRATVCDCHGQVFNDCPRPWKGGFILPILGAVLALLTLLLALLLLVRKKRKVKEPLLLPEDDTRDNVFYYGEEGGGEEDQDYDITQLHRGLEARPEVVLRNDVVPTFIPTPMYRPRPANPDEIGNFIIENLKAANTDPTAPPYDSLLVFDYEGSGSDAASLSSLTTSASDQDQDYNYLNEWGSRFKKLADMYGGGEDD |
| Enzyme Length | 822 |
| Uniprot Accession Number | P10287 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (17); Chain (1); Domain (5); Glycosylation (2); Helix (2); Propeptide (1); Sequence conflict (3); Signal peptide (1); Topological domain (2); Transmembrane (1); Turn (5) |
| Keywords | 3D-structure;Calcium;Cell adhesion;Cell membrane;Cleavage on pair of basic residues;Glycoprotein;Membrane;Metal-binding;Reference proteome;Repeat;Signal;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..25; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 4NQQ; |
| Mapped Pubmed ID | 10333730; 10545227; 10707907; 10771476; 11032855; 11748141; 11839813; 12060406; 12126948; 12466851; 12520002; 12646922; 12904583; 12919105; 1427864; 14610273; 14681479; 14997319; 15148305; 15306695; 15630473; 15728677; 15775979; 15805154; 16319116; 16462742; 16602821; 16809539; 16919267; 17278136; 17292359; 18083014; 18199584; 18224708; 18593557; 18676816; 18799693; 18809908; 18829530; 18849982; 1904011; 19165927; 19427292; 19474150; 19521566; 19596317; 19666824; 19783739; 19786578; 20046825; 20212509; 20826529; 20930145; 20962855; 21262812; 21300875; 21445019; 21521738; 21680756; 21703454; 21743464; 21750040; 21926481; 22115758; 22144916; 22168923; 22495305; 22710718; 22792072; 23034632; 23108156; 23271346; 23277553; 23389444; 23431057; 23487314; 23974039; 24012369; 24198274; 24222445; 24371086; 24442140; 24492243; 24875170; 24952961; 24982158; 25126785; 25253890; 25691658; 26256211; 26405179; 26450968; 26765568; 26783302; 26792522; 26952977; 26992132; 27097562; 27234308; 27317810; 27807348; 2793940; 2806125; 2806126; 28494434; 28604778; 29180573; 29338041; 29899403; 30186101; 30297418; 30595533; 30735538; 31672914; 31835801; 32109382; 32845239; 32878924; 33227706; 33297480; 33833667; 34757798; 3539943; 7743137; 7750649; 7781895; 8107195; 8227214; 8567126; 8619966; 8808390; 8955792; 9015265; 9069116; 9226036; 9226037; 9328434; 9362520; 9383070; 9449663; 9682977; |
| Motif | |
| Gene Encoded By | |
| Mass | 90,612 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |