| IED ID | IndEnz0016000114 |
| Enzyme Type ID | tyrosinase000114 |
| Protein Name |
Membrane-associated transporter protein Melanoma antigen AIM1 Protein AIM-1 Solute carrier family 45 member 2 |
| Gene Name | SLC45A2 AIM1 MATP |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGMALYLNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGLHYHALFTGFGGALGYLLGAIDWAHLELGRLLGTEFQVMFFFSALVLTLCFTVHLCSISEAPLTEVAKGIPPQQTPQDPPLSSDGMYEYGSIEKVKNGYVNPELAMQGAKNKNHAEQTRRAMTLKSLLRALVNMPPHYRYLCISHLIGWTAFLSNMLFFTDFMGQIVYRGDPYSAHNSTEFLIYERGVEVGCWGLCINSVFSSLYSYFQKVLVSYIGLKGLYFTGYLLFGLGTGFIGLFPNVYSTLVLCSLFGVMSSTLYTVPFNLITEYHREEEKERQQAPGGDPDNSVRGKGMDCATLTCMVQLAQILVGGGLGFLVNTAGTVVVVVITASAVALIGCCFVALFVRYVD |
| Enzyme Length | 530 |
| Uniprot Accession Number | Q9UMX9 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (6); Chain (1); Frameshift (1); Glycosylation (1); Natural variant (26); Topological domain (13); Transmembrane (12) |
| Keywords | Albinism;Alternative splicing;Disease variant;Glycoprotein;Melanin biosynthesis;Membrane;Reference proteome;Sensory transduction;Transmembrane;Transmembrane helix;Vision |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Melanosome membrane {ECO:0000269|PubMed:17081065}; Multi-pass membrane protein {ECO:0000269|PubMed:17081065}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11916009; 12028586; 16847698; 17358008; 17516931; 18326704; 18463683; 18650849; 18806926; 18986462; 19060277; 19297406; 19340012; 19384953; 19710684; 19913121; 20381161; 20457063; 20585627; 20628086; 20861488; 21287499; 21559390; 21677667; 22042571; 22294196; 22464347; 22490798; 23165166; 23190901; 23660638; 24096233; 24118800; 25093503; 25760657; 26057890; 27019209; 27566401; 27760139; 28457509; 28630054; 28747635; 30544954; 30809845; 31630438; 32686196; 32966160; 34505419; 6766744; 9770375; |
| Motif | |
| Gene Encoded By | |
| Mass | 58,268 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |