| IED ID | IndEnz0016000117 |
| Enzyme Type ID | tyrosinase000117 |
| Protein Name |
Tyrosinase inhibitor Phenol oxidase inhibitor Phenoloxidase inhibitor POI |
| Gene Name | |
| Organism | Musca domestica (House fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Calyptratae Muscoidea Muscidae (house flies) Muscinae Muscini Musca Musca Musca domestica (House fly) |
| Enzyme Sequence | AVTDNEIVPQCLANGSKCYSHDVCCTKRCHNYAKKCVT |
| Enzyme Length | 38 |
| Uniprot Accession Number | P81765 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Potent reversible, competitive inhibitor of tyrosinase (phenol oxidase) in the nanomolar range. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Disulfide bond (3); Modified residue (1); Peptide (1) |
| Keywords | Direct protein sequencing;Disulfide bond;Hydroxylation;Knottin;Secreted |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | MOD_RES 32; /note="3',4'-dihydroxyphenylalanine"; /evidence="ECO:0000269|PubMed:7708756" |
| Post Translational Modification | PTM: Contains L-DOPA (3',4'-dihydroxyphenylalanine). |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 4,204 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |