Detail Information for IndEnz0016000165
IED ID IndEnz0016000165
Enzyme Type ID tyrosinase000165
Protein Name Tyrosine phenol-lyase
EC 4.1.99.2
Beta-tyrosinase
Gene Name tpl Intca_0142
Organism Intrasporangium calvum (strain ATCC 23552 / DSM 43043 / JCM 3097 / NBRC 12989 / 7 KIP)
Taxonomic Lineage cellular organisms Bacteria Terrabacteria group Actinobacteria Actinomycetia (high G+C Gram-positive bacteria) Micrococcales Intrasporangiaceae Intrasporangium Intrasporangium calvum Intrasporangium calvum (strain ATCC 23552 / DSM 43043 / JCM 3097 / NBRC 12989 / 7 KIP)
Enzyme Sequence MPAIAEPYRIKMVEPITMTTREQREAAIRAAGYNTFLLRSDDVYIDLLTDSGTSAMSDRQWSAMMMGDEAYAGARSFDHLVESVRENYGFPLVCPTHQGRGAEHLISKILITPGQHVPGNMYFTTTRVHQELAGGTFHDVIIDEAHDPASRHPFKGNVDLDKFQALIDEVGADQIAYINVAVTVNMAGGQPVSMANIRAVREICDRYGIILWSDATRLAENAWFIQEREDGYAGRPVAEIVREMLSHFDGITMSGKKDCLVNIGGFLAMRDEAILTKARELVVVYEGMPTYGGLAGRDLDAMAVGLREALDDDYLTHRIGQVRYLGERLQAAGVPIVEPIGGHAVFIDAAAFLDHLSQDELPAQTLAAEIFLDSGVRSMERGIVSAGRDADGNNRYPKLELVRLTIPRRVYTNSHMDVVADSVIRVFQRRREIQGLTFVYESPTLRFFTSRFEPLAAEAALEEGRPEPALAGA
Enzyme Length 473
Uniprot Accession Number E6SFG5
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=H2O + L-tyrosine = NH4(+) + phenol + pyruvate; Xref=Rhea:RHEA:21704, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377, ChEBI:CHEBI:15882, ChEBI:CHEBI:28938, ChEBI:CHEBI:58315; EC=4.1.99.2; Evidence={ECO:0000255|HAMAP-Rule:MF_00543};
DNA Binding
EC Number 4.1.99.2
Enzyme Function
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Modified residue (1)
Keywords Lyase;Pyridoxal phosphate;Reference proteome
Interact With
Induction
Subcellular Location
Modified Residue MOD_RES 257; /note=N6-(pyridoxal phosphate)lysine; /evidence=ECO:0000255|HAMAP-Rule:MF_00543
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 52,319
Kinetics
Metal Binding
Rhea ID RHEA:21704
Cross Reference Brenda