| IED ID | IndEnz0016000165 |
| Enzyme Type ID | tyrosinase000165 |
| Protein Name |
Tyrosine phenol-lyase EC 4.1.99.2 Beta-tyrosinase |
| Gene Name | tpl Intca_0142 |
| Organism | Intrasporangium calvum (strain ATCC 23552 / DSM 43043 / JCM 3097 / NBRC 12989 / 7 KIP) |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Actinobacteria Actinomycetia (high G+C Gram-positive bacteria) Micrococcales Intrasporangiaceae Intrasporangium Intrasporangium calvum Intrasporangium calvum (strain ATCC 23552 / DSM 43043 / JCM 3097 / NBRC 12989 / 7 KIP) |
| Enzyme Sequence | MPAIAEPYRIKMVEPITMTTREQREAAIRAAGYNTFLLRSDDVYIDLLTDSGTSAMSDRQWSAMMMGDEAYAGARSFDHLVESVRENYGFPLVCPTHQGRGAEHLISKILITPGQHVPGNMYFTTTRVHQELAGGTFHDVIIDEAHDPASRHPFKGNVDLDKFQALIDEVGADQIAYINVAVTVNMAGGQPVSMANIRAVREICDRYGIILWSDATRLAENAWFIQEREDGYAGRPVAEIVREMLSHFDGITMSGKKDCLVNIGGFLAMRDEAILTKARELVVVYEGMPTYGGLAGRDLDAMAVGLREALDDDYLTHRIGQVRYLGERLQAAGVPIVEPIGGHAVFIDAAAFLDHLSQDELPAQTLAAEIFLDSGVRSMERGIVSAGRDADGNNRYPKLELVRLTIPRRVYTNSHMDVVADSVIRVFQRRREIQGLTFVYESPTLRFFTSRFEPLAAEAALEEGRPEPALAGA |
| Enzyme Length | 473 |
| Uniprot Accession Number | E6SFG5 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=H2O + L-tyrosine = NH4(+) + phenol + pyruvate; Xref=Rhea:RHEA:21704, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377, ChEBI:CHEBI:15882, ChEBI:CHEBI:28938, ChEBI:CHEBI:58315; EC=4.1.99.2; Evidence={ECO:0000255|HAMAP-Rule:MF_00543}; |
| DNA Binding | |
| EC Number | 4.1.99.2 |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Modified residue (1) |
| Keywords | Lyase;Pyridoxal phosphate;Reference proteome |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | MOD_RES 257; /note=N6-(pyridoxal phosphate)lysine; /evidence=ECO:0000255|HAMAP-Rule:MF_00543 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 52,319 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:21704 |
| Cross Reference Brenda |