Detail Information for IndEnz0016000167
IED ID IndEnz0016000167
Enzyme Type ID tyrosinase000167
Protein Name Tyrosinase
EC 1.14.18.1
Monophenol monooxygenase
Gene Name TYR
Organism Podospora anserina (Pleurage anserina)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta sordariomyceta Sordariomycetes Sordariomycetidae Sordariales Podosporaceae Podospora Podospora anserina (Pleurage anserina)
Enzyme Sequence MSTTGNIAITGIPTTAGPDGSFPLRRELRDLQRNYPDHFNLLVLALKDFQALNESVQTSYYQIAGIHGLPYKPWNNVGSNSDWQSTSGFGGYCTHSSILFLTWHRPYLALFEQALYNSIQKIANQFPQGPLRTKYVEAAKTFRMPYFDWASQPPSGSSAFPSAFTAPSLQVVDVDGKTKSTANPIYRFVFHPVNPSPGDFPRQWSRFPTTVRYPNPRTGQSQDNRVAPILANELASLRTNVSLLLLSYTNFDAFSFNRWDPNMTPGEFGSLEDVHNEIHDRTGGGGHMSSLDVSSFDPLFWFHHTNVDRLWAIWQDLNPDNFLTPRPAPYSTFNSTEGESQTKDTPLTPFWDKSATKFWTSEEIKDTTTTFGYAYPETQEWKYRTGSEYQTSIRQAVTTLYGTNVFANFAAANVQARATEHTELIKSLSLAAPPPSAPITAEKPLLITQEMKASPIPEHLQHLAPNNKYPEWVVNIRAQKHGLHGAFRVIVFLGPIDESDPDSWQTEFNTVGRVSVLGRSTQGPTTTKCAKCITDAADELMISGTVPLTSALLQDIVNENTASIACSQRKWCRI
Enzyme Length 574
Uniprot Accession Number Q92396
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone; Xref=Rhea:RHEA:34287, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57504, ChEBI:CHEBI:57924; EC=1.14.18.1; CATALYTIC ACTIVITY: Reaction=L-tyrosine + O2 = H2O + L-dopaquinone; Xref=Rhea:RHEA:18117, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57924, ChEBI:CHEBI:58315; EC=1.14.18.1;
DNA Binding
EC Number 1.14.18.1
Enzyme Function FUNCTION: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Cross-link (1); Metal binding (6)
Keywords Copper;Melanin biosynthesis;Metal-binding;Monooxygenase;Oxidoreductase;Thioether bond
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 64,181
Kinetics
Metal Binding METAL 67; /note=Copper A; /evidence=ECO:0000250|UniProtKB:Q9ZP19; METAL 95; /note=Copper A; /evidence=ECO:0000250|UniProtKB:Q9ZP19; METAL 104; /note=Copper A; /evidence=ECO:0000250|UniProtKB:Q9ZP19; METAL 275; /note=Copper B; /evidence=ECO:0000250|UniProtKB:Q9ZP19; METAL 279; /note=Copper B; /evidence=ECO:0000250|UniProtKB:Q9ZP19; METAL 304; /note=Copper B; /evidence=ECO:0000250|UniProtKB:Q9ZP19
Rhea ID RHEA:34287; RHEA:18117
Cross Reference Brenda