Detail Information for IndEnz0016000168
IED ID IndEnz0016000168
Enzyme Type ID tyrosinase000168
Protein Name Tyrosinase
EC 1.14.18.1
Monophenol monooxygenase
Gene Name mepA melA
Organism Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic Lineage cellular organisms Bacteria Proteobacteria Alphaproteobacteria Hyphomicrobiales Rhizobiaceae Sinorhizobium/Ensifer group Sinorhizobium Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti)
Enzyme Sequence MTSADGQKDLQSYMDAVTAMLKLPPSDRRNWYRNGFIHLMDCPHGDWWFTSWHRGYLGYFEETCRELSGNPDFALPYWDWTANPEVLPPLFGTILDPVNSSAYIPDHNRFQDIMQEPIKAYWDSLSPAQLQQQNLRGYPDFDALWSDAMASFANQPNARFLTAQNPKLNPATQTAVDIDTIKASLAPTTFANDAGAPGLAFNSPVSSSHQVAPVGFSILEGQPHNRVHMSVGGQSAPYGLMSQNLSPLDPIFFLHHCNIDRLWDVWTRKQQAMGLPVGPTADQQTQYDPEPYLFYVNADGSPVSDKTRAADYLEIGDFDYDYDPGSGEEVIPVATAGRSAPIPALEAAVSASAAVAINKPATAKLTVSQELVDVAAKPSEQSRQFAKVSIAPPMDVGGLNFLVFISPEGTTPDLNPDGPDFAGSFEFFGVRHHHTDTVSFTIPIDKALDRLIDDGRLKAGEPIDFAVVVAQEGKRVEGSMPAKAQLTDIQVGSF
Enzyme Length 494
Uniprot Accession Number P33180
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone; Xref=Rhea:RHEA:34287, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57504, ChEBI:CHEBI:57924; EC=1.14.18.1; CATALYTIC ACTIVITY: Reaction=L-tyrosine + O2 = H2O + L-dopaquinone; Xref=Rhea:RHEA:18117, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57924, ChEBI:CHEBI:58315; EC=1.14.18.1;
DNA Binding
EC Number 1.14.18.1
Enzyme Function
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Metal binding (6)
Keywords Copper;Melanin biosynthesis;Metal-binding;Monooxygenase;Oxidoreductase;Plasmid
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By Plasmid pRmeGR4b
Mass 54,109
Kinetics
Metal Binding METAL 38; /note=Copper A; /evidence=ECO:0000250|UniProtKB:Q9ZP19; METAL 53; /note=Copper A; /evidence=ECO:0000250|UniProtKB:Q9ZP19; METAL 64; /note=Copper A; /evidence=ECO:0000250|UniProtKB:Q9ZP19; METAL 224; /note=Copper B; /evidence=ECO:0000250|UniProtKB:Q9ZP19; METAL 228; /note=Copper B; /evidence=ECO:0000250|UniProtKB:Q9ZP19; METAL 256; /note=Copper B; /evidence=ECO:0000250|UniProtKB:Q9ZP19
Rhea ID RHEA:34287; RHEA:18117
Cross Reference Brenda