| IED ID | IndEnz0016000171 |
| Enzyme Type ID | tyrosinase000171 |
| Protein Name |
Tyrosinase EC 1.14.18.1 Monophenol monooxygenase |
| Gene Name | tyr1 AFUA_1G17430 |
| Organism | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Fumigati Neosartorya fumigata (Aspergillus fumigatus) Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
| Enzyme Sequence | MSSNKPYVIKGIPVDAGQIIPVRRDIDEWYEDTSRQSRIQLSIFIWALREFQSIDYKDRLSYFQIAGIHHFPLITWDEEEPPVPNKPGYCVHNNVTFPTWHRPYMLLFEQRLFEIMETTIKETVPESHKQEWRDAARQWRLPYWDFAKTSGPHATGPLSLPVLCGLANVVILNPANPETPIELPNPVYKYRAPDLMGNLDKPFHIPPERIDPDKDDYYPWDKCQATTKYGLLKNNPHIQDAGQDVTKSNLALNEHPWYRPNKAGFPPLQTLTYEVHRLLSFKFSSWGAFASTKWCNEENKPPASQQTRDILSLEYIHNNVHNWVGGTDYLGDPSKPDLQGAGHMSSVPVAAFDPIFWLYHNNVDRLTAIWQVLNQDHWFDEPHPSDAKPDDPLKPFHVSKDKYFTSDDARFWRKYGYDYDIVKKPGTNEDRAPEEVKMKINQLYGEPISRLHEGQPVEYDYVINVIYDRYALDGIPYTIVFYLHLKDGSYKCLGGVYTFSTKLSDAQDTERGGCDNCREQKKAGVLASAQIPLTYTLYERQEWHNLGKLLPVKETADIIRQHLCWKVVGVNNSILFDSEQPMRGDPATWRSLDVTAAYSEIHYPVDRNYKYIDRGLPAYHNYLPIHLSPT |
| Enzyme Length | 630 |
| Uniprot Accession Number | Q8J130 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone; Xref=Rhea:RHEA:34287, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57504, ChEBI:CHEBI:57924; EC=1.14.18.1; CATALYTIC ACTIVITY: Reaction=L-tyrosine + O2 = H2O + L-dopaquinone; Xref=Rhea:RHEA:18117, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57924, ChEBI:CHEBI:58315; EC=1.14.18.1; |
| DNA Binding | |
| EC Number | 1.14.18.1 |
| Enzyme Function | FUNCTION: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Cross-link (1); Metal binding (6); Sequence conflict (2) |
| Keywords | Copper;Melanin biosynthesis;Metal-binding;Monooxygenase;Oxidoreductase;Reference proteome;Thioether bond |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 73,032 |
| Kinetics | |
| Metal Binding | METAL 69; /note=Copper A; /evidence=ECO:0000250|UniProtKB:Q9ZP19; METAL 92; /note=Copper A; /evidence=ECO:0000250|UniProtKB:Q9ZP19; METAL 101; /note=Copper A; /evidence=ECO:0000250|UniProtKB:Q9ZP19; METAL 317; /note=Copper B; /evidence=ECO:0000250|UniProtKB:Q9ZP19; METAL 321; /note=Copper B; /evidence=ECO:0000250|UniProtKB:Q9ZP19; METAL 360; /note=Copper B; /evidence=ECO:0000250|UniProtKB:Q9ZP19 |
| Rhea ID | RHEA:34287; RHEA:18117 |
| Cross Reference Brenda |