| IED ID |
IndEnz0016000214 |
| Enzyme Type ID |
tyrosinase000214 |
| Protein Name |
Terrein cluster-specific transcription factor terR
|
| Gene Name |
terR ATEG_00139 |
| Organism |
Aspergillus terreus (strain NIH 2624 / FGSC A1156) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Fungi
Dikarya
Ascomycota
saccharomyceta
Pezizomycotina
leotiomyceta
Eurotiomycetes
Eurotiomycetidae
Eurotiales (green and blue molds)
Aspergillaceae
Aspergillus
Aspergillus subgen. Circumdati
Aspergillus terreus
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
|
| Enzyme Sequence |
MFAELNAKDQFNELLKHLSSTSCTTMQADRVETSSSVRKKKWMSRRRGACDMCKSKKVRCDGGTPCSYCNLHDLRCEYQLSKKQQTNKPPVASAAEDVSIVPSYAENNGSGVTTQVPSPSDVQVLPELTANRGSGNAGNILQDMMLATNDRHSMPVMFDGYAHDNFSASPIEWVGSDSLAAPFSVDMGNLNALGTLPWSPPKTAYSEPNLDIPYPIEHTTDVSASLPSISQFELNLPLSPAGPTRDMYDEKMWEEVSPKRQRLGNLSPTQQDEVEAIFRRLSDAQSQMSFGLGGEQYDSHSRWYWSDTALMEKCKSACFEEPLGISTFLTRSHFDDYVQQARESPSIQGLAVRPLIDSVMAFGFHILAARSQPSAGSDVSRKAITRLRMALSSRDAVQRSPDTLLKLQMTISEQIDHKIHTELLSYAVSCARSRRFLHRDSVYMTMTKEKEYLARRSMWYLYSMEVVHSIRDGMPPILTPDWTDYALPEVGKDTDTDWLLIQCQHANALSSAVNALYSPRALCQTVAERERNMMQAHKLLENWRTSLPVHLQNIHRHETGYVALDDQKTRHLTLTMVGKYHEAIFIIFFPWTGSQSKGLISEHYRKRSMELCVKSAQAVLAIAARITSCDILGGSLAS |
| Enzyme Length |
638 |
| Uniprot Accession Number |
Q0D1P5 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
DNA_BIND 50..76; /note=Zn(2)-C6 fungal-type; /evidence=ECO:0000255|PROSITE-ProRule:PRU00227 |
| EC Number |
|
| Enzyme Function |
FUNCTION: Transcription factor that regulates specifically the terrein biosynthesis gene cluster (PubMed:24816227, PubMed:26173180, PubMed:25852654). Recognizes CGG direct repeat consensus sequences in the terrein cluster forming the high affinity consensus motif TCGGHHWYHCGGH (PubMed:25852654). {ECO:0000269|PubMed:24816227, ECO:0000269|PubMed:25852654, ECO:0000269|PubMed:26173180}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); DNA binding (1) |
| Keywords |
DNA-binding;Metal-binding;Nucleus;Reference proteome;Transcription;Transcription regulation;Zinc |
| Interact With |
|
| Induction |
INDUCTION: Expression is induced by methionine (PubMed:26173180). Nitrogen starvation induces expression of terR and promotes terrein production during fruit infection, via regulation by areA and atfA (PubMed:26173180). Iron limitation acts as a third independent signal for terrein cluster induction via the iron response regulator hapX (PubMed:26173180). {ECO:0000269|PubMed:26173180}. |
| Subcellular Location |
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
|
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
|
| Gene Encoded By |
|
| Mass |
71,533 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|