| IED ID | IndEnz0016000217 |
| Enzyme Type ID | tyrosinase000217 |
| Protein Name |
Tyrosinase EC 1.14.18.1 Monophenol monooxygenase Fragment |
| Gene Name | TYR |
| Organism | Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Archelosauria Testudinata Testudines (turtles) Cryptodira (hidden-necked turtles) Trionychia Trionychidae (soft-shelled turtles) Pelodiscus Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis) |
| Enzyme Sequence | MCLLALGFLLGILQPASGQFPRACASSESLLRKECCPLWAGDGSPCGELSGRGSCQEILLSRAPLGPQFPFTGVDDREDWPAVFYNRTCQCNSNFMGFNCGECRFGFSGPNCAERRMRMRRSIFQLSTREKNKFLAYLNLAKHTPSQDYVIATGTYAQMNNGLTPMFRNISVYDLFVWMHYYVSRDTLLGDASVWRDIDFAHEAPGFLPWHRLFLVLWEHEIQKITGDENFTIPYWDWRDAEGCDVCTDELMGDRHPTNPQLLSPASFFSSWQ |
| Enzyme Length | 273 |
| Uniprot Accession Number | P55026 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone; Xref=Rhea:RHEA:34287, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57504, ChEBI:CHEBI:57924; EC=1.14.18.1; CATALYTIC ACTIVITY: Reaction=L-tyrosine + O2 = H2O + L-dopaquinone; Xref=Rhea:RHEA:18117, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57924, ChEBI:CHEBI:58315; EC=1.14.18.1; |
| DNA Binding | |
| EC Number | 1.14.18.1 |
| Enzyme Function | FUNCTION: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Glycosylation (3); Metal binding (3); Non-terminal residue (1); Signal peptide (1) |
| Keywords | Copper;Glycoprotein;Melanin biosynthesis;Membrane;Metal-binding;Monooxygenase;Oxidoreductase;Reference proteome;Signal;Transmembrane |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Melanosome membrane; Single-pass type I membrane protein. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..18; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 31,136 |
| Kinetics | |
| Metal Binding | METAL 180; /note=Copper A; /evidence=ECO:0000250|UniProtKB:Q9ZP19; METAL 202; /note=Copper A; /evidence=ECO:0000250|UniProtKB:Q9ZP19; METAL 211; /note=Copper A; /evidence=ECO:0000250|UniProtKB:Q9ZP19 |
| Rhea ID | RHEA:34287; RHEA:18117 |
| Cross Reference Brenda |