| IED ID | IndEnz0017000001 |
| Enzyme Type ID | manganese peroxidase000001 |
| Protein Name |
Manganese peroxidase 1 MnP-1 MnP1 EC 1.11.1.13 Manganese peroxidase isozyme 1 Peroxidase manganese-dependent 1 Peroxidase manganese-dependent I |
| Gene Name | MNP1 |
| Organism | Phanerodontia chrysosporium (White-rot fungus) (Sporotrichum pruinosum) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Basidiomycota Agaricomycotina Agaricomycetes Agaricomycetes incertae sedis Polyporales Phanerochaetaceae Phanerodontia Phanerodontia chrysosporium (White-rot fungus) (Sporotrichum pruinosum) |
| Enzyme Sequence | MAFKSLIAFVALAAAVRAAPTAVCPDGTRVSHAACCAFIPLAQDLQETIFQNECGEDAHEVIRLTFHDAIAISRSQGPKAGGGADGSMLLFPTVEPNFSANNGIDDSVNNLIPFMQKHNTISAADLVQFAGAVALSNCPGAPRLEFLAGRPNKTIAAVDGLIPEPQDSVTKILQRFEDAGGFTPFEVVSLLASHSVARADKVDQTIDAAPFDSTPFTFDTQVFLEVLLKGVGFPGSANNTGEVASPLPLGSGSDTGEMRLQSDFALAHDPRTACIWQGFVNEQAFMAASFRAAMSKLAVLGHNRNSLIDCSDVVPVPKPATGQPAMFPASTGPQDLELSCPSERFPTLTTQPGASQSLIAHCPDGSMSCPGVQFNGPA |
| Enzyme Length | 378 |
| Uniprot Accession Number | Q02567 |
| Absorption | |
| Active Site | ACT_SITE 67; /note=Proton acceptor |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=2 H(+) + H2O2 + 2 Mn(2+) = 2 H2O + 2 Mn(3+); Xref=Rhea:RHEA:22776, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16240, ChEBI:CHEBI:29035, ChEBI:CHEBI:29041; EC=1.11.1.13; |
| DNA Binding | |
| EC Number | 1.11.1.13 |
| Enzyme Function | FUNCTION: Catalyzes the oxidation of Mn(2+) to Mn(3+). The latter, acting as a diffusible redox mediator, is capable of oxidizing a variety of lignin compounds. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Beta strand (7); Chain (1); Disulfide bond (5); Glycosylation (3); Helix (19); Metal binding (13); Sequence conflict (1); Signal peptide (1); Site (1); Turn (7) |
| Keywords | 3D-structure;Calcium;Direct protein sequencing;Disulfide bond;Glycoprotein;Heme;Hydrogen peroxide;Iron;Lignin degradation;Manganese;Metal-binding;Oxidoreductase;Peroxidase;Secreted;Signal |
| Interact With | |
| Induction | INDUCTION: During wound-healing and by factors which induce suberization. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..21; /evidence=ECO:0000269|PubMed:2925681 |
| Structure 3D | X-ray crystallography (9) |
| Cross Reference PDB | 1MN1; 1MN2; 1MNP; 1YYD; 1YYG; 1YZP; 1YZR; 3M5Q; 3M8M; |
| Mapped Pubmed ID | 15850380; 20356630; 8182752; |
| Motif | |
| Gene Encoded By | |
| Mass | 39,557 |
| Kinetics | |
| Metal Binding | METAL 56; /note=Manganese; METAL 60; /note=Manganese; METAL 68; /note=Calcium 1; METAL 83; /note=Calcium 1; via carbonyl oxygen; METAL 85; /note=Calcium 1; METAL 87; /note=Calcium 1; METAL 194; /note=Iron (heme b axial ligand); METAL 195; /note=Calcium 2; METAL 200; /note=Manganese; METAL 212; /note=Calcium 2; METAL 214; /note=Calcium 2; METAL 217; /note=Calcium 2; via carbonyl oxygen; METAL 219; /note=Calcium 2 |
| Rhea ID | RHEA:22776 |
| Cross Reference Brenda | 1.11.1.13; |