| IED ID | IndEnz0018000056 |
| Enzyme Type ID | peroxidase000056 |
| Protein Name |
L-ascorbate peroxidase 1, cytosolic AP AtAPx01 EC 1.11.1.11 |
| Gene Name | APX1 At1g07890 F24B9.2 |
| Organism | Arabidopsis thaliana (Mouse-ear cress) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
| Enzyme Sequence | MTKNYPTVSEDYKKAVEKCRRKLRGLIAEKNCAPIMVRLAWHSAGTFDCQSRTGGPFGTMRFDAEQAHGANSGIHIALRLLDPIREQFPTISFADFHQLAGVVAVEVTGGPDIPFHPGREDKPQPPPEGRLPDATKGCDHLRDVFAKQMGLSDKDIVALSGAHTLGRCHKDRSGFEGAWTSNPLIFDNSYFKELLSGEKEGLLQLVSDKALLDDPVFRPLVEKYAADEDAFFADYAEAHMKLSELGFADA |
| Enzyme Length | 250 |
| Uniprot Accession Number | Q05431 |
| Absorption | |
| Active Site | ACT_SITE 42; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00297, ECO:0000255|PROSITE-ProRule:PRU10012" |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=H2O2 + L-ascorbate = 2 H2O + L-dehydroascorbate; Xref=Rhea:RHEA:22996, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:38290, ChEBI:CHEBI:58539; EC=1.11.1.11; Evidence={ECO:0000305|PubMed:15608336}; |
| DNA Binding | |
| EC Number | 1.11.1.11 |
| Enzyme Function | FUNCTION: Plays a key role in hydrogen peroxide removal. Constitutes a central component of the reactive oxygen gene network. {ECO:0000269|PubMed:15608336}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Compositional bias (1); Initiator methionine (1); Metal binding (6); Modified residue (1); Region (1); Site (1) |
| Keywords | Alternative splicing;Calcium;Cytoplasm;Direct protein sequencing;Heme;Hydrogen peroxide;Iron;Metal-binding;Oxidoreductase;Peroxidase;Phosphoprotein;Potassium;Reference proteome |
| Interact With | Q42403 |
| Induction | INDUCTION: By ethylene, ozone, sulfur dioxide, Fe exposure, oxidative and heat-shock stresses, and by excess light treatment. Induced by cadmium (PubMed:16502469). {ECO:0000269|PubMed:14739345, ECO:0000269|PubMed:16502469, ECO:0000269|PubMed:8534847, ECO:0000269|PubMed:9144965, ECO:0000269|PubMed:9808745}. |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm. |
| Modified Residue | MOD_RES 196; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:22092075 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12068123; 12626114; 12694594; 14722088; 15187287; 15352244; 15634699; 15919670; 16034597; 16207701; 16242667; 16247729; 16287169; 16336779; 16483133; 16897488; 17080932; 17355434; 17556505; 17644812; 17916636; 18318659; 18431481; 18775970; 18849295; 18852264; 19125253; 19284649; 19884228; 20080316; 20118269; 20706207; 20736450; 21051935; 21153767; 21220338; 21492976; 21798944; 22115780; 22661072; 22921811; 23183257; 23289948; 23448691; 23615222; 23682113; 23918967; 24064926; 24088017; 24792388; 25320212; 25482750; 25515798; 25667317; 25788022; 25874657; 26649488; 27149098; 27247031; 27462324; 27535793; 27676073; 28167043; 28627464; 28717360; 29929127; 30824054; 31040279; 31138623; 31257201; 32562829; 32595686; 9291097; |
| Motif | |
| Gene Encoded By | |
| Mass | 27,561 |
| Kinetics | |
| Metal Binding | METAL 163; /note=Iron (heme b axial ligand); /evidence=ECO:0000255|PROSITE-ProRule:PRU00297; METAL 164; /note=Potassium; /evidence=ECO:0000250; METAL 180; /note=Potassium; /evidence=ECO:0000250; METAL 182; /note=Potassium; /evidence=ECO:0000250; METAL 185; /note=Potassium; via carbonyl oxygen; /evidence=ECO:0000250; METAL 187; /note=Potassium; /evidence=ECO:0000250 |
| Rhea ID | RHEA:22996 |
| Cross Reference Brenda | 1.11.1.11; |