IED ID | IndEnz0018000085 |
Enzyme Type ID | peroxidase000085 |
Protein Name |
Catalase HPII EC 1.11.1.6 Hydroxyperoxidase II |
Gene Name | katE b1732 JW1721 |
Organism | Escherichia coli (strain K12) |
Taxonomic Lineage | cellular organisms Bacteria Proteobacteria Gammaproteobacteria Enterobacterales Enterobacteriaceae Escherichia Escherichia coli Escherichia coli (strain K12) |
Enzyme Sequence | MSQHNEKNPHQHQSPLHDSSEAKPGMDSLAPEDGSHRPAAEPTPPGAQPTAPGSLKAPDTRNEKLNSLEDVRKGSENYALTTNQGVRIADDQNSLRAGSRGPTLLEDFILREKITHFDHERIPERIVHARGSAAHGYFQPYKSLSDITKADFLSDPNKITPVFVRFSTVQGGAGSADTVRDIRGFATKFYTEEGIFDLVGNNTPIFFIQDAHKFPDFVHAVKPEPHWAIPQGQSAHDTFWDYVSLQPETLHNVMWAMSDRGIPRSYRTMEGFGIHTFRLINAEGKATFVRFHWKPLAGKASLVWDEAQKLTGRDPDFHRRELWEAIEAGDFPEYELGFQLIPEEDEFKFDFDLLDPTKLIPEELVPVQRVGKMVLNRNPDNFFAENEQAAFHPGHIVPGLDFTNDPLLQGRLFSYTDTQISRLGGPNFHEIPINRPTCPYHNFQRDGMHRMGIDTNPANYEPNSINDNWPRETPPGPKRGGFESYQERVEGNKVRERSPSFGEYYSHPRLFWLSQTPFEQRHIVDGFSFELSKVVRPYIRERVVDQLAHIDLTLAQAVAKNLGIELTDDQLNITPPPDVNGLKKDPSLSLYAIPDGDVKGRVVAILLNDEVRSADLLAILKALKAKGVHAKLLYSRMGEVTADDGTVLPIAATFAGAPSLTVDAVIVPCGNIADIADNGDANYYLMEAYKHLKPIALAGDARKFKATIKIADQGEEGIVEADSADGSFMDELLTLMAAHRVWSRIPKIDKIPA |
Enzyme Length | 753 |
Uniprot Accession Number | P21179 |
Absorption | |
Active Site | ACT_SITE 128; /evidence=ECO:0000255|PROSITE-ProRule:PRU10013; ACT_SITE 201; /evidence=ECO:0000255|PROSITE-ProRule:PRU10013 |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | CATALYTIC ACTIVITY: Reaction=2 H2O2 = 2 H2O + O2; Xref=Rhea:RHEA:20309, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240; EC=1.11.1.6; Evidence={ECO:0000255|PROSITE-ProRule:PRU10013}; |
DNA Binding | |
EC Number | 1.11.1.6 |
Enzyme Function | FUNCTION: Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Active site (2); Beta strand (29); Chain (1); Compositional bias (1); Cross-link (1); Helix (36); Metal binding (1); Region (2); Turn (8) |
Keywords | 3D-structure;Cytoplasm;Direct protein sequencing;Heme;Hydrogen peroxide;Iron;Metal-binding;Oxidoreductase;Peroxidase;Reference proteome |
Interact With | Itself |
Induction | INDUCTION: By entry into stationary phase. |
Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | |
Structure 3D | X-ray crystallography (46) |
Cross Reference PDB | 1CF9; 1GG9; 1GGE; 1GGF; 1GGH; 1GGJ; 1GGK; 1IPH; 1P7Y; 1P7Z; 1P80; 1P81; 1QF7; 1QWS; 1YE9; 3P9P; 3P9Q; 3P9R; 3P9S; 3PQ2; 3PQ3; 3PQ4; 3PQ5; 3PQ6; 3PQ7; 3PQ8; 3TTT; 3TTU; 3TTV; 3TTW; 3TTX; 3VU3; 4BFL; 4ENP; 4ENQ; 4ENR; 4ENS; 4ENT; 4ENU; 4ENV; 4ENW; 5BV2; 6BY0; 6ZTV; 6ZTW; 6ZTX; |
Mapped Pubmed ID | 10022351; 10488114; 10802173; 11440837; 11763776; 12589799; 12777389; 12916153; 1324193; 1385595; 14980071; 15690043; 15823018; 15915708; 16183297; 16606699; 16858726; 17400245; 21332158; 2187997; 22172685; 2254248; 22820098; 24223139; 24561554; 2977357; 29968670; 33485289; 6094482; |
Motif | |
Gene Encoded By | |
Mass | 84,163 |
Kinetics | |
Metal Binding | METAL 415; /note=Iron (heme axial ligand) |
Rhea ID | RHEA:20309 |
Cross Reference Brenda |