| IED ID | IndEnz0018000086 |
| Enzyme Type ID | peroxidase000086 |
| Protein Name |
Phosphatidylinositol transfer protein CSR1 CHS5 SPA2 rescue protein 1 SEC14 homolog protein 2 |
| Gene Name | CSR1 SFH2 YLR380W |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces Saccharomyces cerevisiae (Baker's yeast) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Enzyme Sequence | MSFDRQLTEDQEVVLKQIWTHLFHLWQVPVDGTHIFPNNSLHSSSTPAKKKKSSWFSKLQSSDHTQDSSEAAEAAHLYEKGKIHKALANLDPQTTKKQFWHDIKNETPDATILKFIRARKWNADKTIAMLGHDLYWRKDTINKIINGGERAVYENNETGVIKNLELQKATIQGYDNDMRPVILVRPRLHHSSDQTEQELEKFSLLVIEQSKLFFKENYPASTTILFDLNGFSMSNMDYAPVKFLITCFEAHYPESLGHLLIHKAPWIFNPIWNIIKNWLDPVVASKIVFTKNIDELHKFIQPQYIPRYLGGENDNDLDHYTPPDGSLDVHLKDTETRAMIEKEREELVEQFLTVTAQWIEHQPLNDPAYIQLQEKRVQLSTALCENYSKLDPYIRSRSVYDYNGSLKV |
| Enzyme Length | 408 |
| Uniprot Accession Number | Q06705 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out); Xref=Rhea:RHEA:38691, ChEBI:CHEBI:57880; Evidence={ECO:0000269|PubMed:10848624};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38692; Evidence={ECO:0000269|PubMed:10848624}; |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Activates SPO14/PLD1 (phospholipase D1) by stimulating phosphoinositide synthesis via the STT4 PtdIns 4-kinase. Modulates ArfGAP function through effects on SPO14 activity. Inhibits phosphatidylcholine degradation by PLB1 (phospholipase B1). May also regulate post-Golgi membrane-trafficking events and have a role resistance to oxidative stress. Inhibits fatty acid synthase activity in response to heme depletion and oleic acid starvation, preventing saturated fatty acid (SFA) accumulation (PubMed:17803462). {ECO:0000269|PubMed:10679005, ECO:0000269|PubMed:10848624, ECO:0000269|PubMed:12435498, ECO:0000269|PubMed:12824182, ECO:0000269|PubMed:12869188, ECO:0000269|PubMed:16126894, ECO:0000269|PubMed:16262726, ECO:0000269|PubMed:17803462}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Domain (1); Initiator methionine (1); Modified residue (2); Sequence conflict (1) |
| Keywords | Acetylation;Cytoplasm;Endoplasmic reticulum;Endosome;Lipid degradation;Lipid metabolism;Lipid transport;Microsome;Phospholipid degradation;Phospholipid metabolism;Phosphoprotein;Reference proteome;Transport |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12869188}. Microsome {ECO:0000269|PubMed:12869188}. Endosome {ECO:0000269|PubMed:10848624}. |
| Modified Residue | MOD_RES 2; /note=N-acetylserine; /evidence=ECO:0007744|PubMed:15665377; MOD_RES 2; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:15665377 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12711700; 16455519; 16554755; 16709158; 16709166; 16884526; 17335879; 17395532; 17512778; 19129178; 19416650; 19536198; 19818713; 21119626; 21734642; 21912624; 22842922; 23275493; 23631861; 24390141; 25083872; |
| Motif | |
| Gene Encoded By | |
| Mass | 47,463 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:38691; RHEA:38692 |
| Cross Reference Brenda |