Detail Information for IndEnz0018000117
IED ID IndEnz0018000117
Enzyme Type ID peroxidase000117
Protein Name Alkyl hydroperoxide reductase AhpD
EC 1.11.1.28
Alkylhydroperoxidase AhpD
Gene Name ahpD FRAAL4493
Organism Frankia alni (strain ACN14a)
Taxonomic Lineage cellular organisms Bacteria Terrabacteria group Actinobacteria Actinomycetia (high G+C Gram-positive bacteria) Frankiales Frankiaceae Frankia Frankia alni Frankia alni (strain ACN14a)
Enzyme Sequence MTVARLRELLPDYARDLRLNLGSVTSQSNLSAQQLWGTVLAAAIASRGRTVLVELEPEALDHLSAEAATAARTAAALMAMNNVYYRSLHLLEDEEYSRLRAGLRMNALANPGVDKVDVELWSLAVSAVNGCGRCLTAHEHELRGRGVAREVIQDAIRVASVVHAVAVTVEALETSSGTNRVAAAD
Enzyme Length 185
Uniprot Accession Number Q0RH96
Absorption
Active Site ACT_SITE 131; /note=Proton donor; /evidence=ECO:0000255|HAMAP-Rule:MF_01676; ACT_SITE 134; /note=Cysteine sulfenic acid (-SOH) intermediate; /evidence=ECO:0000255|HAMAP-Rule:MF_01676
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O; Xref=Rhea:RHEA:62636, Rhea:RHEA-COMP:10502, Rhea:RHEA-COMP:16355, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:83099, ChEBI:CHEBI:83100; EC=1.11.1.28; Evidence={ECO:0000255|HAMAP-Rule:MF_01676};
DNA Binding
EC Number 1.11.1.28
Enzyme Function FUNCTION: Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. {ECO:0000255|HAMAP-Rule:MF_01676}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (2); Chain (1); Disulfide bond (2)
Keywords Antioxidant;Disulfide bond;Oxidoreductase;Peroxidase;Redox-active center;Reference proteome
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 19,828
Kinetics
Metal Binding
Rhea ID RHEA:62636
Cross Reference Brenda