Detail Information for IndEnz0018000118
IED ID IndEnz0018000118
Enzyme Type ID peroxidase000118
Protein Name Alkyl hydroperoxide reductase AhpD
EC 1.11.1.28
Alkylhydroperoxidase AhpD
Gene Name ahpD MAB_4407c
Organism Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543) (Mycobacterium abscessus)
Taxonomic Lineage cellular organisms Bacteria Terrabacteria group Actinobacteria Actinomycetia (high G+C Gram-positive bacteria) Corynebacteriales Mycobacteriaceae Mycobacteroides Mycobacteroides abscessus Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543) (Mycobacterium abscessus)
Enzyme Sequence MSIENLKEALPEYAKDLKLNLGTVARGTVLSQSQLWGTLVATAAATRNEQVFKEIREEAAGILTPEALDAALGAASIMAMTNVFYRGRGFLDGAYDDLRPGLRMNIIGNPGVDKSEFELWSFAVSTINGCHYCVGSHEKVLREAGLTREQVLEALKIAAIVAGVAQALATVPALV
Enzyme Length 175
Uniprot Accession Number B1MJX0
Absorption
Active Site ACT_SITE 130; /note=Proton donor; /evidence=ECO:0000255|HAMAP-Rule:MF_01676; ACT_SITE 133; /note=Cysteine sulfenic acid (-SOH) intermediate; /evidence=ECO:0000255|HAMAP-Rule:MF_01676
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O; Xref=Rhea:RHEA:62636, Rhea:RHEA-COMP:10502, Rhea:RHEA-COMP:16355, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:83099, ChEBI:CHEBI:83100; EC=1.11.1.28; Evidence={ECO:0000255|HAMAP-Rule:MF_01676};
DNA Binding
EC Number 1.11.1.28
Enzyme Function FUNCTION: Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. {ECO:0000255|HAMAP-Rule:MF_01676}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (2); Chain (1); Disulfide bond (2)
Keywords Antioxidant;Disulfide bond;Oxidoreductase;Peroxidase;Redox-active center
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 18,705
Kinetics
Metal Binding
Rhea ID RHEA:62636
Cross Reference Brenda