Detail Information for IndEnz0018000151
IED ID IndEnz0018000151
Enzyme Type ID peroxidase000151
Protein Name Alkyl hydroperoxide reductase E
EC 1.11.1.29
Mycoredoxin-dependent peroxiredoxin
Peroxiredoxin AhpE
Prx
Thioredoxin peroxidase
TPx
Gene Name ahpE MT2298
Organism Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Taxonomic Lineage cellular organisms Bacteria Terrabacteria group Actinobacteria Actinomycetia (high G+C Gram-positive bacteria) Corynebacteriales Mycobacteriaceae Mycobacterium Mycobacterium tuberculosis complex Mycobacterium tuberculosis Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Enzyme Sequence MLNVGATAPDFTLRDQNQQLVTLRGYRGAKNVLLVFFPLAFTGICQGELDQLRDHLPEFENDDSAALAISVGPPPTHKIWATQSGFTFPLLSDFWPHGAVSQAYGVFNEQAGIANRGTFVVDRSGIIRFAEMKQPGEVRDQRLWTDALAALTA
Enzyme Length 153
Uniprot Accession Number P9WIE2
Absorption
Active Site ACT_SITE 45; /evidence=ECO:0000250
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=[mycoredoxin]-L-dithiol + a hydroperoxide = [mycoredoxin]-L-disulfide + an alcohol + H2O; Xref=Rhea:RHEA:62640, Rhea:RHEA-COMP:16137, Rhea:RHEA-COMP:16138, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:50058; EC=1.11.1.29; Evidence={ECO:0000250|UniProtKB:P9WIE3};
DNA Binding
EC Number 1.11.1.29
Enzyme Function FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. May represent an important antioxidant defense against cytotoxic peroxides, especially peroxynitrite, which can be formed by activated macrophages during infection. {ECO:0000250|UniProtKB:P9WIE3}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Domain (1)
Keywords Antioxidant;Oxidoreductase;Peroxidase;Redox-active center
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 16,819
Kinetics
Metal Binding
Rhea ID RHEA:62640
Cross Reference Brenda