| IED ID | IndEnz0018000176 |
| Enzyme Type ID | peroxidase000176 |
| Protein Name |
Glutathione peroxidase GPX EC 1.11.1.9 |
| Gene Name | GPX1 |
| Organism | Schistosoma mansoni (Blood fluke) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Spiralia Lophotrochozoa Platyhelminthes Trematoda Digenea (flukes) Strigeidida Schistosomatoidea Schistosomatidae (blood flukes) Schistosoma Schistosoma mansoni (Blood fluke) |
| Enzyme Sequence | MSSSHKSWNSIYEFTVKDINGVDVSLEKYRGHVCLIVNVACKUGATDKNYRQLQEMHTRLVGKGLRILAFPCNQFGGQEPWAEAEIKKFVTEKYGVQFDMFSKIKVNGSDADDLYKFLKSRQHGTLTNNIKWNFSKFLVDRQGQPVKRYSPTTAPYDIEGDIMELLEKK |
| Enzyme Length | 169 |
| Uniprot Accession Number | Q00277 |
| Absorption | |
| Active Site | ACT_SITE 43; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O; Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9; |
| DNA Binding | |
| EC Number | 1.11.1.9 |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Beta strand (9); Chain (1); Helix (8); Non-standard residue (1); Turn (1) |
| Keywords | 3D-structure;Oxidoreductase;Peroxidase;Reference proteome;Selenocysteine |
| Interact With | |
| Induction | INDUCTION: Activity increases significantly as worms mature in their host and is positively correlated to the resistance to antioxidants. |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (2) |
| Cross Reference PDB | 2V1M; 2WGR; |
| Mapped Pubmed ID | 19714775; |
| Motif | |
| Gene Encoded By | |
| Mass | 19,471 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:16833 |
| Cross Reference Brenda | 1.11.1.9; |