| IED ID | IndEnz0018000252 |
| Enzyme Type ID | peroxidase000252 |
| Protein Name |
Cytochrome c peroxidase, mitochondrial CCP EC 1.11.1.5 |
| Gene Name | CCP1 CCP CPO YKR066C |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces Saccharomyces cerevisiae (Baker's yeast) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Enzyme Sequence | MTTAVRLLPSLGRTAHKRSLYLFSAAAAAAAAATFAYSQSQKRSSSSPGGGSNHGWNNWGKAAALASTTPLVHVASVEKGRSYEDFQKVYNAIALKLREDDEYDNYIGYGPVLVRLAWHTSGTWDKHDNTGGSYGGTYRFKKEFNDPSNAGLQNGFKFLEPIHKEFPWISSGDLFSLGGVTAVQEMQGPKIPWRCGRVDTPEDTTPDNGRLPDADKDADYVRTFFQRLNMNDREVVALMGAHALGKTHLKNSGYEGPWGAANNVFTNEFYLNLLNEDWKLEKNDANNEQWDSKSGYMMLPTDYSLIQDPKYLSIVKEYANDQDKFFKDFSKAFEKLLENGITFPKDAPSPFIFKTLEEQGL |
| Enzyme Length | 361 |
| Uniprot Accession Number | P00431 |
| Absorption | |
| Active Site | ACT_SITE 119; /note=Proton acceptor; ACT_SITE 258; /note=Tryptophan radical intermediate |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=2 Fe(II)-[cytochrome c] + 2 H(+) + H2O2 = 2 Fe(III)-[cytochrome c] + 2 H2O; Xref=Rhea:RHEA:16581, Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16240, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034; EC=1.11.1.5; |
| DNA Binding | |
| EC Number | 1.11.1.5 |
| Enzyme Function | FUNCTION: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Beta strand (10); Chain (1); Helix (18); Metal binding (1); Modified residue (1); Mutagenesis (1); Natural variant (3); Sequence conflict (5); Site (1); Transit peptide (1); Turn (6) |
| Keywords | 3D-structure;Direct protein sequencing;Heme;Hydrogen peroxide;Iron;Metal-binding;Mitochondrion;Organic radical;Oxidoreductase;Peroxidase;Phosphoprotein;Reference proteome;Transit peptide |
| Interact With | P00044 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion matrix. Mitochondrion intermembrane space {ECO:0000269|PubMed:22984289}. |
| Modified Residue | MOD_RES 220; /note=Phosphotyrosine; /evidence=ECO:0007744|PubMed:18407956 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (180); NMR spectroscopy (3) |
| Cross Reference PDB | 1A2F; 1A2G; 1AA4; 1AC4; 1AC8; 1AEB; 1AED; 1AEE; 1AEF; 1AEG; 1AEH; 1AEJ; 1AEK; 1AEM; 1AEN; 1AEO; 1AEQ; 1AES; 1AET; 1AEU; 1AEV; 1BEJ; 1BEK; 1BEM; 1BEP; 1BEQ; 1BES; 1BJ9; 1BVA; 1CCA; 1CCB; 1CCC; 1CCE; 1CCG; 1CCI; 1CCJ; 1CCK; 1CCL; 1CCP; 1CMP; 1CMQ; 1CMT; 1CMU; 1CPD; 1CPE; 1CPF; 1CPG; 1CYF; 1DCC; 1DJ1; 1DJ5; 1DS4; 1DSE; 1DSG; 1DSO; 1DSP; 1EBE; 1JCI; 1JDR; 1KOK; 1KRJ; 1KXM; 1KXN; 1MK8; 1MKQ; 1MKR; 1ML2; 1RYC; 1S6V; 1S73; 1SBM; 1SDQ; 1SOG; 1STQ; 1U74; 1U75; 1Z53; 1ZBY; 1ZBZ; 2ANZ; 2AQD; 2AS1; 2AS2; 2AS3; 2AS4; 2AS6; 2B0Z; 2B10; 2B11; 2B12; 2BCN; 2CCP; 2CEP; 2CYP; 2EUN; 2EUO; 2EUP; 2EUQ; 2EUR; 2EUS; 2EUT; 2EUU; 2GB8; 2IA8; 2ICV; 2JTI; 2N18; 2PCB; 2PCC; 2RBT; 2RBU; 2RBV; 2RBW; 2RBX; 2RBY; 2RBZ; 2RC0; 2RC1; 2RC2; 2V23; 2V2E; 2X07; 2X08; 2XIL; 2XJ5; 2XJ8; 2Y5A; 2YCG; 3CCP; 3CCX; 3E2N; 3E2O; 3EXB; 3M23; 3M25; 3M26; 3M27; 3M28; 3M29; 3M2A; 3M2B; 3M2C; 3M2D; 3M2E; 3M2F; 3M2G; 3M2H; 3M2I; 3R98; 3R99; 4A6Z; 4A71; 4A78; 4A7M; 4CCP; 4CCX; 4CVI; 4CVJ; 4JB4; 4NFG; 4P4Q; 4XV4; 4XV5; 4XV6; 4XV7; 4XV8; 4XVA; 5CCP; 5CIB; 5CIC; 5CID; 5CIE; 5CIF; 5CIG; 5CIH; 5D6M; 5EJT; 5EJX; 6CCP; 6H08; 6P41; 6P42; 6P43; 6Y1T; 6Y2Y; 7BIU; 7CCP; |
| Mapped Pubmed ID | 10220341; 10471293; 10512537; 10569951; 10570992; 10589830; 10605835; 10606521; 10608846; 10679215; 11148036; 11485318; 11557322; 11580287; 11679167; 11732914; 11812152; 11851415; 11900539; 11967381; 12044899; 12237229; 12417197; 12427011; 12684005; 12741816; 12957710; 12962501; 12962502; 1334573; 14138; 14505074; 14558145; 14759599; 15071191; 15236591; 15339156; 15839648; 15900441; 16173060; 16227441; 16313629; 16429126; 16478190; 16490206; 16507144; 16725216; 16893189; 17011626; 17021923; 17128976; 17146057; 17245427; 17275914; 17580971; 17972915; 18056997; 18232645; 18280498; 18605900; 18719252; 18771292; 19019989; 19026661; 19061385; 19072042; 19536198; 20206121; 20230048; 20672804; 20707985; 207699; 21062738; 21176163; 21334283; 2154451; 2176836; 21820401; 21889423; 21916516; 22001671; 22093282; 22094416; 22209905; 22607123; 22829965; 22970195; 23022490; 23217712; 23505335; 23517193; 23831190; 23832496; 24099009; 24382195; 24433162; 24726731; 24950326; 24964148; 25013070; 25180929; 25247923; 25422453; 2545724; 25629200; 25640729; 25755154; 25900360; 25907133; 25944250; 26032594; 26212209; 26261310; 26787871; 26813659; 26885726; 27050502; 27499202; 2844231; 3024731; 3034903; 31603693; 32550044; 33826799; 34337604; 34403572; 6091738; 6290489; 7547943; 7632697; 7632698; 7664080; 7703247; 7809133; 7972020; 8038157; 8069633; 8142383; 8286338; 8396972; 8396973; 8399235; 8528082; 8547245; 8664277; 9305956; 9514261; 9601073; 9836578; |
| Motif | |
| Gene Encoded By | |
| Mass | 40,353 |
| Kinetics | |
| Metal Binding | METAL 242; /note=Iron (heme b axial ligand) |
| Rhea ID | RHEA:16581 |
| Cross Reference Brenda | 1.11.1.5; |