| IED ID | IndEnz0018000262 |
| Enzyme Type ID | peroxidase000262 |
| Protein Name |
Catalase-B EC 1.11.1.6 |
| Gene Name | catB DDB_G0269108 |
| Organism | Dictyostelium discoideum (Slime mold) |
| Taxonomic Lineage | cellular organisms Eukaryota Amoebozoa Evosea Eumycetozoa Dictyostelia (dictyostelid cellular slime molds) Dictyosteliales Dictyosteliaceae Dictyostelium Dictyostelium discoideum (Slime mold) |
| Enzyme Sequence | MNKKLEQLEKFKTNDKNPVYSTTNTGVSLSDDANSLKAGPRGPTLLEDFVLREKITHFDHERIPERIVHARGTGAHGYFLSYKDHSKLTKADFLSKQDKKTPVFIRISTVQGPRGSADTVRDVHGFAVKFYTDEGNYDLVGNNMPVFFIQDASSFPDFVHAVKMEPQNEMPTGGSAHDTFYDFCGLKPESAHSVLWVMSDRGIPISLRHQQGFGVHSYRFINQEGKSTFVKLHWKPLSGTCSLLWDEAQKIAGKDCDYHRRRFWEDIESGDFPQWELGAQLLDEDLQKKFDFDILDPTKLIPEELTPVIPLGRMVIDRNPDNFFAETEQVAFCVSHVVPGIDFSNDPLLQGRIFSYLDTQLSRLGGPNFNEIPINRPVCPFANNQRDGIHRMTINKGGASYFPNSIDKGYPLLKEPSANKGGFRPYPENISGTKSYDRSETFEDHFSQATMFWNSMSQHEKNHIIAAYTFEISKCSRPEVRTRYVNNILVNIDSVLAEKVAKNLGVKIEPTSTKPIKKIMVKPSPALSQPNLLSGDIVSRRISVIIEKGVDYDDVINFKDDMEKRGAMVMLVSSTLAQVECSGGEMLSPKGTIIGNPSIFFDAVYVPKSTEEATKILSDDGNFLHYILEAFKHLKTIAFGGSVSVIKELLRLPQDHGLLLGNGYKDITEQFFYSLAHHRVWERESKVSKIPA |
| Enzyme Length | 692 |
| Uniprot Accession Number | Q55DH8 |
| Absorption | |
| Active Site | ACT_SITE 69; /evidence=ECO:0000255|PROSITE-ProRule:PRU10013; ACT_SITE 142; /evidence=ECO:0000255|PROSITE-ProRule:PRU10013 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=2 H2O2 = 2 H2O + O2; Xref=Rhea:RHEA:20309, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240; EC=1.11.1.6; Evidence={ECO:0000255|PROSITE-ProRule:PRU10013, ECO:0000269|PubMed:11004503}; |
| DNA Binding | |
| EC Number | 1.11.1.6 |
| Enzyme Function | FUNCTION: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Its accumulation in prespore cells affords the spores protection from oxidation during prolonged dormancy. Required for normal developmental timing, possibly through a regulatory role in differentiation and morphogenesis. {ECO:0000269|PubMed:12788229}. |
| Temperature Dependency | BIOPHYSICOCHEMICAL PROPERTIES: Temperature dependence: Thermostable. Still active after heating at 65 degrees Celsius for 15 minures.; |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Erroneous initiation (1); Metal binding (1) |
| Keywords | Cytoplasm;Heme;Hydrogen peroxide;Iron;Metal-binding;Oxidoreductase;Peroxidase;Reference proteome |
| Interact With | |
| Induction | INDUCTION: By srfA, in response to late development signals. {ECO:0000269|PubMed:15075287}. |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11004503}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11566853; |
| Motif | |
| Gene Encoded By | |
| Mass | 78,033 |
| Kinetics | |
| Metal Binding | METAL 356; /note=Iron (heme axial ligand); /evidence=ECO:0000250 |
| Rhea ID | RHEA:20309 |
| Cross Reference Brenda |