| IED ID | IndEnz0018000285 |
| Enzyme Type ID | peroxidase000285 |
| Protein Name |
Cytochrome c peroxidase, mitochondrial CCP EC 1.11.1.5 |
| Gene Name | CCP1 CND02630 |
| Organism | Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Basidiomycota Agaricomycotina Tremellomycetes Tremellales (jelly fungi) Cryptococcaceae Cryptococcus Cryptococcus neoformans species complex Cryptococcus neoformans (Filobasidiella neoformans) Cryptococcus neoformans var. neoformans Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) |
| Enzyme Sequence | MSFRAPNLIRSAAGRRASQTLNLRSQVIRRRFATEGGPEITKPSSPRSSNTRYLLAGVGIAAVGAAYYFYGTGRTAHDSANKADTVVRGAVATVEAKTGLRRGKDEYQKVYNRIAETLEKEGYDDGSLAPVLLRLAWHSSGTYNKEDGTGGSNFATMRFKPEAEHSANNGLHVAREHMEKIKQEFPWISYGDLWTLGGVCAVQESGGPTIPWRPGRIDGFEAQVTPDGRLPDASQAQDHLRFIFNRMGFNDQEIVALSGAHAMGRCHTNRSGFEGPWTFSPVTFSNQYFALLRDEPWQWKKWTGPAQYEDKNTKTLMMLPTDMALLKDKSFKKYVDIYADNEEKFFSDFAKAFSKLIELGVPERQWAGEPWTLGTSD |
| Enzyme Length | 377 |
| Uniprot Accession Number | P0CP54 |
| Absorption | |
| Active Site | ACT_SITE 138; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00297, ECO:0000255|PROSITE-ProRule:PRU10012"; ACT_SITE 277; /note="Tryptophan radical intermediate"; /evidence="ECO:0000250" |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=2 Fe(II)-[cytochrome c] + 2 H(+) + H2O2 = 2 Fe(III)-[cytochrome c] + 2 H2O; Xref=Rhea:RHEA:16581, Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16240, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034; EC=1.11.1.5; |
| DNA Binding | |
| EC Number | 1.11.1.5 |
| Enzyme Function | FUNCTION: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Metal binding (1); Site (1); Transit peptide (1) |
| Keywords | Heme;Iron;Metal-binding;Mitochondrion;Oxidoreductase;Peroxidase;Reference proteome;Transit peptide |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 42,112 |
| Kinetics | |
| Metal Binding | METAL 261; /note=Iron (heme b axial ligand) |
| Rhea ID | RHEA:16581 |
| Cross Reference Brenda |