| IED ID | IndEnz0018000308 |
| Enzyme Type ID | peroxidase000308 |
| Protein Name |
Protein hook dHK |
| Gene Name | hook hk CG10653 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MSAPKNEMYYSLLEWFKTLNLNAPHADAESLADGVALAQALNQFAPESFTDAWLSKIKASAVGSNWRLRMSNLKKVTQSVYDYYSDVLNYSLSDFSKPDLQRIAEKCDLGELERLLQLVLGCAVNCAEKQSYITEIMCLEEELQANIMRALQELEATRQASTPEGGVASSLSRGSRTGLLDSKAVQEDRDALAQKCFETEKKMLLLIDEKTNLQQELHKLQQEFARLEQHSTVIGDDGVSLGPVQTGSVRYNELRRQLDLLKEELLQSEGAREDLKIKAQQQDTDLLHMQMRIEELMKSSAEVTTLKDEVDVLRESNDKLKICEAQLDTYKKKLEDYNDLKKQVKILEERSADYVQQNAQFEEDAKRYANTKGQVELFKKEIQDLHAKLDAESSKNVKLEFDNKNLESKNLALQRAKDSLLKERDNLREAVDELKCGQLSSNTALTGTTVSRELQPSATVEKLQRLEAENKALREGQGGQTALAQLLDDANKRCENLREQLKTANERILSLSHASQSDDPILKESEFGKQIKQLMELNEQKTLQLEEAVTQSTSLQCKVTQLETNLSAREQEILVYDAKYRKCVEKAKEVIKSIDPRIASALDASVLEKSADLVEEEPKPKMSVMEEQLMTSAFYRLGVNAQRDAIDSKLAILMGSGQTFLARQRQSAPRKSLSAMKSK |
| Enzyme Length | 679 |
| Uniprot Accession Number | Q24185 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Involved in endocytic trafficking by stabilizing organelles of the endocytic pathway. Probably acts as a cytoskeletal linker protein required to tether endosome vesicles to the cytoskeleton. Involved in modulation of endocytosis at stages required for down-regulation of membrane proteins that control synapse size. Not involved in synaptic vesicle recycling. Required in R7 cells for boss endocytosis into multivesicular bodies (MVBs). Has a role in regulating adult longevity. {ECO:0000269|PubMed:10198042, ECO:0000269|PubMed:11018772, ECO:0000269|PubMed:17435236, ECO:0000269|PubMed:8682859, ECO:0000269|PubMed:9927460}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Coiled coil (2); Domain (1); Region (1); Sequence conflict (2) |
| Keywords | Cell junction;Coiled coil;Cytoplasm;Cytoskeleton;Developmental protein;Endocytosis;Endosome;Microtubule;Reference proteome;Synapse |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Endosome {ECO:0000269|PubMed:8682859}. Cell junction, synapse {ECO:0000269|PubMed:11018772}. Note=Enriched at neuromuscular synapses, in both presynaptic and postsynaptic regions. {ECO:0000269|PubMed:11018772}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10218159; 10549280; 10559939; 10564267; 10704384; 10751143; 10929403; 11268039; 11697879; 12193790; 12408844; 12427870; 12642492; 14605208; 14627723; 14691479; 14778559; 15051737; 15496440; 15569939; 15728719; 16046475; 16237665; 16336044; 17220882; 17246120; 17247021; 18216171; 18423436; 19158398; 19557185; 19917727; 20206262; 20214937; 20220848; 20368978; 20371351; 20513768; 21074052; 2116788; 21282466; 21316589; 21562262; 21930794; 22934826; 23071443; 24356450; 24553921; 25294943; 25312911; 25453831; 2557263; 26551273; 26870755; 27172210; 27794539; 27960592; 3007281; 30855229; 3124532; 31794428; 32657227; 32848189; 3932822; 6425116; 6790250; 8176361; 826447; 826448; 8647399; 8683095; 8698237; 9115734; 9295137; 9714595; 9892357; |
| Motif | |
| Gene Encoded By | |
| Mass | 76,665 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |