| IED ID | IndEnz0018000440 |
| Enzyme Type ID | peroxidase000440 |
| Protein Name |
Heat stress transcription factor A-2 AtHsfA2 AtHsf-04 |
| Gene Name | HSFA2 HSF04 At2g26150 T19L18.4 |
| Organism | Arabidopsis thaliana (Mouse-ear cress) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
| Enzyme Sequence | MEELKVEMEEETVTFTGSVAASSSVGSSSSPRPMEGLNETGPPPFLTKTYEMVEDPATDTVVSWSNGRNSFVVWDSHKFSTTLLPRYFKHSNFSSFIRQLNTYGFRKIDPDRWEFANEGFLAGQKHLLKNIKRRRNMGLQNVNQQGSGMSCVEVGQYGFDGEVERLKRDHGVLVAEVVRLRQQQHSSKSQVAAMEQRLLVTEKRQQQMMTFLAKALNNPNFVQQFAVMSKEKKSLFGLDVGRKRRLTSTPSLGTMEENLLHDQEFDRMKDDMEMLFAAAIDDEANNSMPTKEEQCLEAMNVMMRDGNLEAALDVKVEDLVGSPLDWDSQDLHDMVDQMGFLGSEP |
| Enzyme Length | 345 |
| Uniprot Accession Number | O80982 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | DNA_BIND 42..136; /evidence=ECO:0000250 |
| EC Number | |
| Enzyme Function | FUNCTION: Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). Involved in heat stress responses. Seems to be involved in other environmental stress responses. Activates ascorbate peroxidase 2 (APX2) in addition to several heat shock protein (HSPs). {ECO:0000269|PubMed:16649111, ECO:0000269|PubMed:17059409, ECO:0000269|PubMed:17085506}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (1); Cross-link (1); DNA binding (1); Motif (4); Mutagenesis (4); Region (2) |
| Keywords | Activator;Alternative splicing;Cytoplasm;DNA-binding;Isopeptide bond;Nucleus;Phosphoprotein;Reference proteome;Repeat;Stress response;Transcription;Transcription regulation;Ubl conjugation |
| Interact With | |
| Induction | INDUCTION: By heat stress, high light and hydrogen peroxide (H(2)O(2)). {ECO:0000269|PubMed:16649111, ECO:0000269|PubMed:17059409, ECO:0000269|PubMed:17085506}. |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:20521085}. Nucleus {ECO:0000269|PubMed:20521085}. |
| Modified Residue | |
| Post Translational Modification | PTM: Exhibits temperature-dependent phosphorylation. {ECO:0000250}.; PTM: Sumoylated at Lys-315. Sumoylation represses its function. {ECO:0000269|PubMed:20521085}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11118137; 12417700; 16483133; 17722694; 17890230; 18201973; 18502973; 19125253; 19244141; 19342427; 19352026; 19366428; 19704439; 19704521; 19876748; 20089772; 20147301; 20458611; 21398256; 21471117; 21510947; 21908690; 22037706; 22570631; 22710144; 23073024; 23238922; 23370720; 23503691; 23638397; 23832625; 23918368; 24265778; 24377444; 24548003; 24580679; 24769482; 25036962; 25533953; 25575991; 25619826; 25711624; 25977236; 26099269; 26136597; 26576681; 27383578; 27500592; 27650334; 27943531; 28873003; 28914758; 28937985; 29444814; 29785454; 30250280; 30287478; 30356219; 30778176; 30882866; 31250033; 31519798; 31806676; 32284544; 32573848; 32654320; 32967551; 34052393; 34103516; 9222607; |
| Motif | MOTIF 230..245; /note=Bipartite nuclear localization signal; /evidence=ECO:0000255; MOTIF 273..282; /note=AHA1; MOTIF 324..333; /note=AHA2; MOTIF 334..341; /note=Nuclear export signal; /evidence=ECO:0000255 |
| Gene Encoded By | |
| Mass | 39,114 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |