Detail Information for IndEnz0018000455
IED ID IndEnz0018000455
Enzyme Type ID peroxidase000455
Protein Name Glutathione S-transferase kappa 1
EC 2.5.1.18
GST 13-13
GST class-kappa
GSTK1-1
mGSTK1
Glutathione S-transferase subunit 13
Gene Name Gstk1
Organism Mus musculus (Mouse)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse)
Enzyme Sequence MGPAPRILELFYDVLSPYSWLGFEVLCRYQHLWNIKLQLRPTLIAGIMKDSGNQPPAMVPRKGQYIFKEIPLLKQFFQVPLNIPKDFFGETVKKGSINAMRFLTTVSMEQPEMLEKVSREIWMRVWSRDEDITEYQSILAAAVKAGMSTAQAQHFLEKISTQQVKNKLIENTDAACKYGAFGLPTTVAHVDGKTYMLFGSDRLELLAYLLGEKWMGPVPPTANARL
Enzyme Length 226
Uniprot Accession Number Q9DCM2
Absorption
Active Site
Activity Regulation
Binding Site BINDING 53; /note=Glutathione; /evidence=ECO:0000250|UniProtKB:Q9Y2Q3; BINDING 183; /note=Glutathione; via amide nitrogen and carbonyl oxygen; /evidence=ECO:0000250|UniProtKB:Q9Y2Q3
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence={ECO:0000269|PubMed:12720545};
DNA Binding
EC Number 2.5.1.18
Enzyme Function FUNCTION: Glutathione S-transferase that catalyzes the conjugation of glutathione to exogenous and endogenous compounds. {ECO:0000269|PubMed:12720545}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Binding site (2); Chain (1); Modified residue (20); Region (2)
Keywords Acetylation;Direct protein sequencing;Mitochondrion;Reference proteome;Transferase
Interact With Q60994
Induction
Subcellular Location SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:12720545}.
Modified Residue MOD_RES 36; /note=N6-succinyllysine; /evidence=ECO:0007744|PubMed:23806337; MOD_RES 49; /note=N6-succinyllysine; /evidence=ECO:0007744|PubMed:23806337; MOD_RES 68; /note=N6-acetyllysine; alternate; /evidence=ECO:0007744|PubMed:23576753; MOD_RES 68; /note=N6-succinyllysine; alternate; /evidence=ECO:0007744|PubMed:23806337; MOD_RES 74; /note=N6-acetyllysine; alternate; /evidence=ECO:0007744|PubMed:23576753; MOD_RES 74; /note=N6-succinyllysine; alternate; /evidence=ECO:0007744|PubMed:23806337; MOD_RES 85; /note=N6-acetyllysine; /evidence=ECO:0007744|PubMed:23576753; MOD_RES 93; /note=N6-acetyllysine; alternate; /evidence=ECO:0007744|PubMed:23576753; MOD_RES 93; /note=N6-succinyllysine; alternate; /evidence=ECO:0007744|PubMed:23806337; MOD_RES 116; /note=N6-acetyllysine; alternate; /evidence=ECO:0007744|PubMed:23576753; MOD_RES 116; /note=N6-succinyllysine; alternate; /evidence=ECO:0007744|PubMed:23806337; MOD_RES 144; /note=N6-succinyllysine; /evidence=ECO:0007744|PubMed:23806337; MOD_RES 158; /note=N6-acetyllysine; alternate; /evidence=ECO:0007744|PubMed:23576753; MOD_RES 158; /note=N6-succinyllysine; alternate; /evidence=ECO:0007744|PubMed:23806337; MOD_RES 165; /note=N6-acetyllysine; /evidence=ECO:0007744|PubMed:23576753; MOD_RES 167; /note=N6-acetyllysine; alternate; /evidence=ECO:0007744|PubMed:23576753; MOD_RES 167; /note=N6-succinyllysine; alternate; /evidence=ECO:0007744|PubMed:23806337; MOD_RES 177; /note=N6-acetyllysine; alternate; /evidence=ECO:0007744|PubMed:23576753; MOD_RES 177; /note=N6-succinyllysine; alternate; /evidence=ECO:0007744|PubMed:23806337; MOD_RES 193; /note=N6-succinyllysine; /evidence=ECO:0007744|PubMed:23806337
Post Translational Modification PTM: Acetylation of Lys-93 is observed in liver mitochondria from fasted mice but not from fed mice. {ECO:0007744|PubMed:23806337}.
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 11217851; 12466851; 12865426; 14651853; 14681479; 14697523; 15100242; 16615898; 18614015; 19011089; 21267068; 21677750; 21826057; 22807031; 25024375; 28232481; 29087318; 30791996; 31060900; 32444826; 32948751; 33436607;
Motif
Gene Encoded By
Mass 25,704
Kinetics
Metal Binding
Rhea ID RHEA:16437
Cross Reference Brenda