Detail Information for IndEnz0018000531
IED ID IndEnz0018000531
Enzyme Type ID peroxidase000531
Protein Name Glutathione S-transferase 3
EC 2.5.1.18
GST class-alpha
GST-CL3
Gene Name
Organism Gallus gallus (Chicken)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Archelosauria Archosauria Dinosauria Saurischia Theropoda Coelurosauria Aves Neognathae Galloanserae Galliformes Phasianidae (turkeys) Phasianinae Gallus Gallus gallus (Chicken)
Enzyme Sequence MAAKPVLYYFNGRGKMESIRWLLAAAGVEFEEVFLETREQYEKLLQSGILMFQQVPMVEIDGMKLVQTRAILNYIAGKYNLYGKDLKERALIDMYVGGTDDLMGFLLSFPFLSAEDKVKQCAFVVEKATSRYFPAYEKVLKDHGQDFLVGNRLSWADIHLLEAILMVEEKKSDALSGFPLLQAFKKRISSIPTIKKFLAPGSKRKPISDDKYVETVRRVLRMYYDVKPH
Enzyme Length 229
Uniprot Accession Number P26697
Absorption
Active Site
Activity Regulation
Binding Site BINDING 9; /note="Glutathione"; /evidence="ECO:0007744|PDB:1VF1, ECO:0007744|PDB:1VF2, ECO:0007744|PDB:1VF3"
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence={ECO:0000250|UniProtKB:Q16772};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16438; Evidence={ECO:0000250|UniProtKB:Q16772};
DNA Binding
EC Number 2.5.1.18
Enzyme Function FUNCTION: Catalyzes the conjugation of GSH to a wide variety of electrophilic alkylating agents. Also involved in the metabolism of lipid hydroperoxides, prostaglandins and leukotriene A4 and in binding of non-substrate hydrophobic ligands such as bile acids, a number of drugs and thyroid hormones. This GST does not exhibit peroxidase activity.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Beta strand (5); Binding site (1); Chain (1); Domain (2); Helix (11); Initiator methionine (1); Modified residue (1); Natural variant (12); Region (2); Turn (3)
Keywords 3D-structure;Cytoplasm;Direct protein sequencing;Reference proteome;Transferase
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm.
Modified Residue MOD_RES 2; /note=Blocked amino end (Ala)
Post Translational Modification
Signal Peptide
Structure 3D X-ray crystallography (4)
Cross Reference PDB 1VF1; 1VF2; 1VF3; 1VF4;
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 26,326
Kinetics
Metal Binding
Rhea ID RHEA:16437; RHEA:16438
Cross Reference Brenda