| IED ID | IndEnz0018000596 |
| Enzyme Type ID | peroxidase000596 |
| Protein Name |
Propanal dehydrogenase CoA-propanoylating EC 1.2.1.87 Coenzyme-A-acylating propionaldehyde dehydrogenase Propanediol utilization protein PduP |
| Gene Name | pduP |
| Organism | Citrobacter freundii |
| Taxonomic Lineage | cellular organisms Bacteria Proteobacteria Gammaproteobacteria Enterobacterales Enterobacteriaceae Citrobacter Citrobacter freundii complex Citrobacter freundii |
| Enzyme Sequence | MNTSELETLIRNILSEQLAPAKAEVKGNGIFPSVSEAIDAAHQAFLRYQQCPLKTRSAIINALREELTPHLASLAAESAAETGMGNKEDKFLKNKAALDNTPGIEDLTTTALTGDGGMVLFEYSPFGVIGSVAPSTNPTETIINNSISMLAAGNSVYFSPHPGAKAVSLKLITMIEDIAFRCCGIRNLVVTVTEPTFEATQQMMAHPKIAVLAITGGPGIVAMGMKSGKKVIGAGAGNPPCIVDETADLVKAAEDIINGASFDFNLPCIAEKSLIVVDAVAERLVQQMQSFGAMRLNSEEIDKLRAVCLPEGIANKQLVGKSPATLLEAAGIPVPAKAPRLLIGIVKADDPWVTSEQLMPMLPIVTVSDFDSALTLALKVEEGLHHTAIMHSQNVSRLNLAARTLQTSIFVKNGPSYAGIGVGGEGFTTFTIATPTGEGTTSARTFARSRRCVLTNGFSIR |
| Enzyme Length | 461 |
| Uniprot Accession Number | B1VB75 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=CoA + NAD(+) + propanal = H(+) + NADH + propanoyl-CoA; Xref=Rhea:RHEA:36027, ChEBI:CHEBI:15378, ChEBI:CHEBI:17153, ChEBI:CHEBI:57287, ChEBI:CHEBI:57392, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.87; Evidence={ECO:0000250|UniProtKB:Q9XDN1}; |
| DNA Binding | |
| EC Number | 1.2.1.87 |
| Enzyme Function | FUNCTION: A CoA-acylating aldehyde dehydrogenase required for optimal 1,2-propanediol (1,2-PD) degradation. Optimizes growth in the bacterial microcompartment (BMC) dedicated to 1,2-PD degradation by minimizing propionaldehyde toxicity. NAD(+) and NADH are regenerated internally within the Pdu BMC by the PduP and PduQ enzymes, which reduce NAD(+) and oxidize NADH respectively, although there must also be cofactor transport across the BMC (By similarity). Directly targeted to the BMC (PubMed:24933391). {ECO:0000250|UniProtKB:Q9XDN1, ECO:0000269|PubMed:24933391}.; FUNCTION: Expression of a cosmid containing the full 21-gene pdu operon in E.coli allows E.coli to grow on 1,2-propanediol (1,2-PD) with the appearance of bacterial microcompartments (BMC) in its cytoplasm. {ECO:0000269|PubMed:18332146}.; FUNCTION: The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low. {ECO:0000305}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | PATHWAY: Polyol metabolism; 1,2-propanediol degradation. {ECO:0000269|PubMed:18332146}. |
| nucleotide Binding | |
| Features | Chain (1); Region (1) |
| Keywords | Bacterial microcompartment;NAD;Oxidoreductase |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Bacterial microcompartment {ECO:0000269|PubMed:18332146, ECO:0000305|PubMed:24933391}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 48,671 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:36027 |
| Cross Reference Brenda |