| IED ID | IndEnz0018000735 |
| Enzyme Type ID | peroxidase000735 |
| Protein Name |
Glutathione S-transferase 3 EC 2.5.1.18 GST-III |
| Gene Name | gst3 SPAC688.04c |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota Taphrinomycotina Schizosaccharomycetes Schizosaccharomycetales Schizosaccharomycetaceae Schizosaccharomyces Schizosaccharomyces pombe (Fission yeast) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
| Enzyme Sequence | MIVLHHLKNSRSTRIVWMLEELKVPYEIKVYDRVDGRAPPAYTKLSPLGKSPIVVDDGVTYIESAAILEHLVRKYGPSFKPSEEDVAELEKYELWMHFSEASLMPFIWASHVLDLSVNMTPIFFRYIVRQFVNGIKSKYLSKETFLNLDYIDNHLASNEYFAGEQFTAADPQMCFPIFAAQRDYLSQKPYKNIKRWMRVVSDRPACRIAAEKVEDNTLTLFSDVERYSHPPTPPPEQVRSDE |
| Enzyme Length | 242 |
| Uniprot Accession Number | Q9P6M1 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; |
| DNA Binding | |
| EC Number | 2.5.1.18 |
| Enzyme Function | FUNCTION: May have a role in the detoxification of various heavy metals. {ECO:0000269|PubMed:12151111}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Domain (2); Modified residue (2) |
| Keywords | Cytoplasm;Phosphoprotein;Reference proteome;Transferase |
| Interact With | |
| Induction | INDUCTION: By heavy metals such as cadmium and mercury. {ECO:0000269|PubMed:12151111}. |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14655046}. |
| Modified Residue | MOD_RES 228; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18257517; MOD_RES 232; /note=Phosphothreonine; /evidence=ECO:0000269|PubMed:18257517 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12063243; 12521310; 18684775; 19547744; 20473289; 21712547; 23697806; 24763107; 25720772; 26412298; 26644575; 29996109; 30726745; 33823663; 34250083; |
| Motif | |
| Gene Encoded By | |
| Mass | 28,113 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:16437 |
| Cross Reference Brenda |