Detail Information for IndEnz0018000781
IED ID IndEnz0018000781
Enzyme Type ID peroxidase000781
Protein Name Glutathione S-transferase Mu 7
EC 2.5.1.18
GST class-mu 7
GSTM-7
Gene Name Gstm7
Organism Mus musculus (Mouse)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse)
Enzyme Sequence MPMTLGYWDIRGLAHAIRLFLEYTDSSYEEKRYTMGDAPDYDQSQWLNEKFKLGLDFPNLPYLIDGSHKITQSNAILRYLGRKHNLCGETEEERIRVDILENQLMDNRMVLARLCYNADFEKLKPGYLEQLPGMMRLYSEFLGKRPWFAGDKITFVDFIAYDVLERNQVFEAKCLDAFPNLKDFIARFEGLKKISDYMKTSRFLPRPMFTKMATWGSN
Enzyme Length 218
Uniprot Accession Number Q80W21
Absorption
Active Site
Activity Regulation
Binding Site BINDING 116; /note=Substrate; /evidence=ECO:0000250
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence={ECO:0000250|UniProtKB:P28161};
DNA Binding
EC Number 2.5.1.18
Enzyme Function FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. {ECO:0000250|UniProtKB:P28161}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Beta strand (6); Binding site (1); Chain (1); Domain (2); Helix (9); Region (4); Sequence conflict (2); Turn (2)
Keywords 3D-structure;Cytoplasm;Reference proteome;Transferase
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P28161}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D X-ray crystallography (1)
Cross Reference PDB 2DC5;
Mapped Pubmed ID 11217851; 12069689; 12466851; 12844521; 14681479; 16602821; 16842493; 21267068; 21677750; 25855264;
Motif
Gene Encoded By
Mass 25,710
Kinetics
Metal Binding
Rhea ID RHEA:16437
Cross Reference Brenda