Detail Information for IndEnz0018000782
IED ID IndEnz0018000782
Enzyme Type ID peroxidase000782
Protein Name Cytochrome-c peroxidase IdrP2
EC 1.11.1.5
Iodate reductase subunit IdrP2
Gene Name idrP2 I8J34_RS03795
Organism Denitromonas sp. (strain IR12)
Taxonomic Lineage cellular organisms Bacteria Proteobacteria Betaproteobacteria Rhodocyclales Rhodocyclaceae Denitromonas unclassified Denitromonas Denitromonas sp. (strain IR12)
Enzyme Sequence MTTHQSIRRLSRIAALVGLAFVAGTVAAADGKAELQALPEAKAGNADMVELGKHLFFDTRLSGDMGVSCASCHDPAKGFSDGMPLSAGYPSVEYFRNAPTLINSRFKNVFMWDGRLDGADMGTLVRDMLTEAHTMNMDSRLMQERLSQVPEYVAMWQKFRKDDINGMRVYGVVGEYVKTLVSQNAPIDRFLKGDGSALTSQQKDGYEIFTGKGGCVACHNGPLGSDGQVHNTGVPENPEVLKNPNRTVTLLRHYATSGMPNYMNARTDLGHYAISKDPADMNKFATPSLRELKYTAPYMHNGMLTTLDQVVDFYNQGGGQGSELTPLGLSGSEKKALVAFLEALSGEPLNVVAPTLPDYQPRQFGKN
Enzyme Length 367
Uniprot Accession Number P0DV69
Absorption
Active Site
Activity Regulation
Binding Site BINDING 69; /note=Heme c 1; covalent; /evidence=ECO:0000255|PROSITE-ProRule:PRU00433; BINDING 72; /note=Heme c 1; covalent; /evidence=ECO:0000255|PROSITE-ProRule:PRU00433; BINDING 215; /note=Heme c 2; covalent; /evidence=ECO:0000255|PROSITE-ProRule:PRU00433; BINDING 218; /note=Heme c 2; covalent; /evidence=ECO:0000255|PROSITE-ProRule:PRU00433
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=2 Fe(II)-[cytochrome c] + 2 H(+) + H2O2 = 2 Fe(III)-[cytochrome c] + 2 H2O; Xref=Rhea:RHEA:16581, Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16240, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034; EC=1.11.1.5; Evidence={ECO:0000305|PubMed:34215855};
DNA Binding
EC Number 1.11.1.5
Enzyme Function FUNCTION: Involved in iodate respiration (PubMed:34215855). May play a critical role in detoxification of inadvertent H(2)O(2) generated by the iodate reductase IdrA/IdrB (PubMed:34215855). {ECO:0000269|PubMed:34215855}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Binding site (4); Chain (1); Domain (2); Metal binding (2); Signal peptide (1)
Keywords Heme;Iron;Metal-binding;Oxidoreductase;Periplasm;Repeat;Signal
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Periplasm {ECO:0000250|UniProtKB:A0A391NKV7}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..28; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 39,941
Kinetics
Metal Binding METAL 73; /note=Iron (heme c 1 axial ligand); /evidence=ECO:0000255|PROSITE-ProRule:PRU00433; METAL 219; /note=Iron (heme c 2 axial ligand); /evidence=ECO:0000255|PROSITE-ProRule:PRU00433
Rhea ID RHEA:16581
Cross Reference Brenda