| IED ID | IndEnz0018000898 |
| Enzyme Type ID | peroxidase000898 |
| Protein Name |
Glycoprotein 3-alpha-L-fucosyltransferase A EC 2.4.1.214 Core alpha- 1,3 -fucosyltransferase |
| Gene Name | FucTA CG6869 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MRRPKISLKKYFYLTLICALLLIFGFSLKEREIWKTLSPRSSQITTQQQQHQHLHQLQSMDEEHPMATSSTPPPIAATLLPEVADNLVEEPEQTVLEEEESEADRLQEPPAEKAWFFKNGEYYPKPAKTYSNRKARKRHAPRLLPHQDPYSDRIINQLMYVPHNYEEIKSSGKLKTILLYNGLGPWNVKKGRDVFLKAKCPVDTCELTANRDLASTADMILYKDHYIPTGIRRPSNSKQVSMLYYLECPYHTQNVKVPDAINWTATYRRDSTIVAPYEKWQYYDTKVQQQEQDINYSVNKTKKVAWFVSNCGARNGRLQYAHELQKYIEVDIYGACGNFKCSRSTADKCFEILDNDYKFYLAFENSNCKDYITEKFFVNALNRRVLPIVMGARPEDYEVSAPRRSYIHVDEFSSPKELAEYLRILDHDDELYNSYFKWKGTGEFINTYYWCRVCATLHNEEQLRKPRWYTDLNDWWRGPGVCTTRSWRNFKARKDVISDSSDD |
| Enzyme Length | 503 |
| Uniprot Accession Number | Q9VUL9 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[(1->4)-alpha-L-Fuc]-beta-D-GlcNAc}-L-asparaginyl-[protein]; Xref=Rhea:RHEA:24444, Rhea:RHEA-COMP:13526, Rhea:RHEA-COMP:13529, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:60651, ChEBI:CHEBI:137182; EC=2.4.1.214; Evidence={ECO:0000269|PubMed:11382750};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24445; Evidence={ECO:0000305|PubMed:11382750}; |
| DNA Binding | |
| EC Number | 2.4.1.214 |
| Enzyme Function | FUNCTION: Catalyzes alpha-1,3 glycosidic linkages of N-glycans (PubMed:11382750). Plays a role in neuronal development by promoting ventral nerve cord formation, possibly by promoting interactions between migrating cells and the extracellular matrix or by promoting neural activity (PubMed:21203496). {ECO:0000269|PubMed:11382750, ECO:0000269|PubMed:21203496}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | PATHWAY: Protein modification; protein glycosylation. |
| nucleotide Binding | |
| Features | Chain (1); Frameshift (1); Glycosylation (3); Region (1); Sequence conflict (1); Topological domain (2); Transmembrane (1) |
| Keywords | Glycoprotein;Glycosyltransferase;Golgi apparatus;Membrane;Reference proteome;Signal-anchor;Transferase;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Membrane-bound form in trans cisternae of Golgi. {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11698403; 12464307; 14605208; 15604090; 16314421; 16650000; 20220848; 20371351; 20688784; 21074052; 21205799; 22251795; 23071443; 23944235; 24865556; 25312911; 25940448; 26370122; 26551273; 27172211; 31722958; 31773367; 32972999; |
| Motif | |
| Gene Encoded By | |
| Mass | 59,160 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:24444; RHEA:24445 |
| Cross Reference Brenda |