| IED ID | IndEnz0018000909 |
| Enzyme Type ID | peroxidase000909 |
| Protein Name |
Interleukin-4 receptor subunit alpha IL-4 receptor subunit alpha IL-4R subunit alpha IL-4R-alpha IL-4RA CD antigen CD124 Cleaved into: Soluble interleukin-4 receptor subunit alpha Soluble IL-4 receptor subunit alpha Soluble IL-4R-alpha sIL4Ralpha/prot IL-4-binding protein IL4-BP |
| Gene Name | IL4R IL4RA 582J2.1 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MGWLCSGLLFPVSCLVLLQVASSGNMKVLQEPTCVSDYMSISTCEWKMNGPTNCSTELRLLYQLVFLLSEAHTCIPENNGGAGCVCHLLMDDVVSADNYTLDLWAGQQLLWKGSFKPSEHVKPRAPGNLTVHTNVSDTLLLTWSNPYPPDNYLYNHLTYAVNIWSENDPADFRIYNVTYLEPSLRIAASTLKSGISYRARVRAWAQCYNTTWSEWSPSTKWHNSYREPFEQHLLLGVSVSCIVILAVCLLCYVSITKIKKEWWDQIPNPARSRLVAIIIQDAQGSQWEKRSRGQEPAKCPHWKNCLTKLLPCFLEHNMKRDEDPHKAAKEMPFQGSGKSAWCPVEISKTVLWPESISVVRCVELFEAPVECEEEEEVEEEKGSFCASPESSRDDFQEGREGIVARLTESLFLDLLGEENGGFCQQDMGESCLLPPSGSTSAHMPWDEFPSAGPKEAPPWGKEQPLHLEPSPPASPTQSPDNLTCTETPLVIAGNPAYRSFSNSLSQSPCPRELGPDPLLARHLEEVEPEMPCVPQLSEPTTVPQPEPETWEQILRRNVLQHGAAAAPVSAPTSGYQEFVHAVEQGGTQASAVVGLGPPGEAGYKAFSSLLASSAVSPEKCGFGASSGEEGYKPFQDLIPGCPGDPAPVPVPLFTFGLDREPPRSPQSSHLPSSSPEHLGLEPGEKVEDMPKPPLPQEQATDPLVDSLGSGIVYSALTCHLCGHLKQCHGQEDGGQTPVMASPCCGCCCGDRSSPPTTPLRAPDPSPGGVPLEASLCPASLAPSGISEKSKSSSSFHPAPGNAQSSSQTPKIVNFVSVGPTYMRVS |
| Enzyme Length | 825 |
| Uniprot Accession Number | P24394 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. {ECO:0000269|PubMed:8124718}.; FUNCTION: Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. {ECO:0000269|PubMed:8124718}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (3); Beta strand (16); Chain (2); Compositional bias (2); Disulfide bond (2); Domain (1); Glycosylation (6); Helix (6); Modified residue (4); Motif (3); Mutagenesis (33); Natural variant (15); Region (6); Signal peptide (1); Site (8); Topological domain (2); Transmembrane (1); Turn (1) |
| Keywords | 3D-structure;Alternative splicing;Cell membrane;Disulfide bond;Glycoprotein;Immunity;Membrane;Phosphoprotein;Receptor;Reference proteome;Secreted;Signal;Transmembrane;Transmembrane helix |
| Interact With | P05112; P42226 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted. |
| Modified Residue | MOD_RES 497; /note=Phosphotyrosine; /evidence=ECO:0000269|PubMed:8124718; MOD_RES 575; /note=Phosphotyrosine; /evidence=ECO:0000305|PubMed:8624803; MOD_RES 603; /note=Phosphotyrosine; /evidence=ECO:0000305|PubMed:8624803; MOD_RES 631; /note=Phosphotyrosine; /evidence=ECO:0000305|PubMed:8624803 |
| Post Translational Modification | PTM: On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction. {ECO:0000269|PubMed:8624803}.; PTM: The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase. {ECO:0000269|PubMed:10341317}. |
| Signal Peptide | SIGNAL 1..25; /evidence=ECO:0000250 |
| Structure 3D | X-ray crystallography (7); NMR spectroscopy (1) |
| Cross Reference PDB | 1IAR; 1IRS; 3BPL; 3BPN; 3BPO; 5E4E; 6OEL; 6WGL; |
| Mapped Pubmed ID | 10051727; 10550754; 10586089; 10641562; 10699178; 10810222; 10887316; 10905893; 11022011; 11164908; 11294568; 11488673; 11491529; 11678851; 11709756; 11739132; 11908817; 11922633; 12100043; 12133990; 12171893; 12223527; 12242343; 12401728; 12748907; 12973929; 14634100; 14745651; 15005726; 15007352; 15021309; 15261459; 15479272; 15584925; 15712015; 15737301; 15805299; 16169070; 16403098; 16451196; 16613701; 16646030; 16681592; 16961803; 17001290; 17045041; 17091279; 17115186; 17209513; 17303794; 17362266; 17586032; 18006935; 18179773; 18243101; 18433792; 19258923; 19420105; 19515749; 19559392; 19573080; 19773279; 20711500; 21058338; 21150319; 22383755; 23124025; 23597562; 25218441; 26554818; 31387945; 32915778; 7795521; 7796300; 8085155; 8266078; 8599766; 8602263; 8797861; 8816495; 9013879; 9515586; 9651359; 9736340; 9822675; 9874253; |
| Motif | MOTIF 212..216; /note=WSXWS motif; MOTIF 262..270; /note=Box 1 motif; MOTIF 711..716; /note=ITIM motif |
| Gene Encoded By | |
| Mass | 89,658 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |