| IED ID | IndEnz0018000956 |
| Enzyme Type ID | peroxidase000956 |
| Protein Name |
Gap junction alpha-8 protein Connexin-50 Cx50 Lens fiber protein MP70 |
| Gene Name | Gja8 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPGCENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHHVRMEEKRKDREAEELCQQSRSNGGERVPIAPDQASIRKSSSSSKGTKKFRLEGTLLRTYVCHIIFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVAFVSLFLNIMEMSHLGMKGIRSAFKRPVEQPLGEIAEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLSAKPFSQFEEKIGTGPLADMSRSYQETLPSYAQVGVQEVEREEPPIEEAVEPEVGEKKQEAEKVAPEGQETVAVPDRERVETPGVGKEDEKEELQAEKVTKQGLSAEKAPSLCPELTTDDNRPLSRLSKASSRARSDDLTI |
| Enzyme Length | 440 |
| Uniprot Accession Number | P28236 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Structural component of eye lens gap junctions (PubMed:1325220). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:1325220). {ECO:0000250|UniProtKB:P55917, ECO:0000269|PubMed:1325220}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (3); Disulfide bond (3); Initiator methionine (1); Intramembrane (1); Region (2); Topological domain (5); Transmembrane (4) |
| Keywords | Cell junction;Cell membrane;Direct protein sequencing;Disulfide bond;Gap junction;Membrane;Reference proteome;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1325220}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55917}. Cell junction, gap junction {ECO:0000305|PubMed:1325220}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10099690; 10393059; 10931824; 11395508; 11687537; 11696604; 11753387; 11782410; 11786642; 11846517; 11875045; 12097863; 12356818; 12766071; 12782682; 12808044; 1399425; 14595769; 14681012; 15081111; 15253273; 15255617; 15326140; 15452070; 15452195; 15466892; 15677379; 16332269; 16611690; 16687738; 16696970; 16740340; 17003442; 17217947; 17546509; 17688421; 18003700; 18055813; 18462719; 19321662; 19331825; 20844585; 20861491; 20861565; 20923641; 21267068; 21320072; 21965293; 22404924; 22713599; 23300808; 23734214; 24005045; 24194600; 24204043; 24380846; 25103261; 25260631; 25823610; 26017495; 27281269; 27317663; 27626380; 28552735; 29176738; 29913165; 30287491; 30562487; 30683901; 30991053; 30995319; 31117126; 31908399; 32182330; 32598448; 33036381; 6877261; 7940024; 8330621; 8631157; 8666393; 9096102; 9119363; 9371744; 9620080; 9729401; 9746435; 9813099; 9860964; 9861669; |
| Motif | |
| Gene Encoded By | |
| Mass | 49,598 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |