| IED ID | IndEnz0018000994 |
| Enzyme Type ID | peroxidase000994 |
| Protein Name |
Glutathione S-transferase Z1 AtGSTZ1 EC 2.5.1.18 GST class-zeta member 1 Glutathione S-transferase 18 Maleylacetone isomerase MAI EC 5.2.1.- |
| Gene Name | GSTZ1 GST18 GSTZ At2g02390 T16F16.18 |
| Organism | Arabidopsis thaliana (Mouse-ear cress) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
| Enzyme Sequence | MANSGEEKLKLYSYWRSSCAHRVRIALALKGLDYEYIPVNLLKGDQFDSDFKKINPMGTVPALVDGDVVINDSFAIIMYLDEKYPEPPLLPRDLHKRAVNYQAMSIVLSGIQPHQNLAVIRYIEEKINVEEKTAWVNNAITKGFTALEKLLVNCAGKHATGDEIYLADLFLAPQIHGAINRFQINMEPYPTLAKCYESYNELPAFQNALPEKQPDAPSSTI |
| Enzyme Length | 221 |
| Uniprot Accession Number | Q9ZVQ3 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | BINDING 46; /note=Glutathione; /evidence=ECO:0000250; BINDING 60; /note=Glutathione; via amide nitrogen and carbonyl oxygen; /evidence=ECO:0000250; BINDING 112; /note=Glutathione; /evidence=ECO:0000250 |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; |
| DNA Binding | |
| EC Number | 2.5.1.18; 5.2.1.- |
| Enzyme Function | FUNCTION: Acts a maleylacetone isomerase. Also catalyzes the glutathione-dependent dehalogenation of dichloroacetic acid to glyoxylic acid. In vitro, possesses glutathione peroxidase activity toward cumene hydroperoxide and linoleic acid-13-hydroperoxide. {ECO:0000269|PubMed:12090627}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (1); Beta strand (6); Binding site (3); Chain (1); Domain (2); Helix (10); Region (6); Turn (1) |
| Keywords | 3D-structure;Alternative splicing;Cytoplasm;Detoxification;Isomerase;Oxidoreductase;Peroxidase;Reference proteome;Stress response;Transferase |
| Interact With | |
| Induction | INDUCTION: By salicylic acid, methyl jasmonate, auxin, H(2)O(2), and the pathogen Hyaloperonospora parasitica. {ECO:0000269|PubMed:12090627}. |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 1E6B; |
| Mapped Pubmed ID | 12169696; 14576160; 15159623; 16021339; 16055689; 16254930; 16500996; 16621846; 18539778; 18650403; 18721788; 20331431; 20622445; 21333657; 22980205; 28627464; |
| Motif | |
| Gene Encoded By | |
| Mass | 24,888 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:16437 |
| Cross Reference Brenda | 5.2.1.2; |