Detail Information for IndEnz0018001000
IED ID IndEnz0018001000
Enzyme Type ID peroxidase001000
Protein Name Cytochrome c peroxidase, mitochondrial
CCP
EC 1.11.1.5
Gene Name CCP1 KLLA0B07557g
Organism Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Kluyveromyces Kluyveromyces lactis (Yeast) (Candida sphaerica) Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Enzyme Sequence MSTTFGNVFRRVNVKTLSFIVGAGALAGSATGTVMEYQDMRNYNNRNYNKQKLAALAAAHVAAKEKYDVAKYQKVYNDIALKIRDEDEYDDFIGYGPVLVRLAWHCAGTWDAKDNTGGPYGGTYRFAMETNDPSNNGLQNAAKFLEPIHEKYPWLSHGDLYSLAGVTAIQEMQGPTIPWRSGRVDQPEDTTPENGRLPDASKDAKYVRCFFHRLNFEDRQVVALLGAHALGKTHLKNSGFEGPWGAATNIFTNEFYNNLLNEKWDLITNDAGNKQYVNDKGWMMLPTDMALVQDPKYLPIVKEFANDQDTFFKEFTKAFVVLLENGIDFPQENKPIKFKTLDAQDL
Enzyme Length 346
Uniprot Accession Number Q6CW24
Absorption
Active Site ACT_SITE 105; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00297, ECO:0000255|PROSITE-ProRule:PRU10012"; ACT_SITE 244; /note="Tryptophan radical intermediate"; /evidence="ECO:0000250"
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=2 Fe(II)-[cytochrome c] + 2 H(+) + H2O2 = 2 Fe(III)-[cytochrome c] + 2 H2O; Xref=Rhea:RHEA:16581, Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16240, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034; EC=1.11.1.5;
DNA Binding
EC Number 1.11.1.5
Enzyme Function FUNCTION: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (2); Chain (1); Metal binding (1); Region (1); Site (1); Transit peptide (1)
Keywords Heme;Iron;Metal-binding;Mitochondrion;Oxidoreductase;Peroxidase;Reference proteome;Transit peptide
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 39,041
Kinetics
Metal Binding METAL 228; /note=Iron (heme b axial ligand)
Rhea ID RHEA:16581
Cross Reference Brenda