| IED ID |
IndEnz0018001012 |
| Enzyme Type ID |
peroxidase001012 |
| Protein Name |
Glutaredoxin-1
|
| Gene Name |
grx1 SPAC4F10.20 |
| Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Fungi
Dikarya
Ascomycota
Taphrinomycotina
Schizosaccharomycetes
Schizosaccharomycetales
Schizosaccharomycetaceae
Schizosaccharomyces
Schizosaccharomyces pombe (Fission yeast)
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
|
| Enzyme Sequence |
MSSVESFVDSAVADNDVVVFAKSYCPYCHATEKVIADKKIKAQVYQIDLMNNGDEIQSYLLKKTGQRTVPNIFIHQKHVGGNSDFQALFKKGELDSLFNTA |
| Enzyme Length |
101 |
| Uniprot Accession Number |
O36032 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
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| Enzyme Function |
FUNCTION: The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase. Thioltransferase catalyzes cellular thiol-disulfide transhydrogenation reactions. It transfers reducing equivalents to cytosolic protein and nonprotein disulfides (By similarity). {ECO:0000250}. |
| Temperature Dependency |
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| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Disulfide bond (1); Domain (1); Sequence conflict (1) |
| Keywords |
Disulfide bond;Electron transport;Redox-active center;Reference proteome;Transport |
| Interact With |
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| Induction |
|
| Subcellular Location |
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| Modified Residue |
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| Post Translational Modification |
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| Signal Peptide |
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| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
11118633;
14503856;
15358115;
15796926;
15865206;
20473289;
21712547;
23697806;
23950735;
25720772;
26173815;
26412298;
28410370;
28640807;
30726745;
33823663;
|
| Motif |
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| Gene Encoded By |
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| Mass |
11,261 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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