Detail Information for IndEnz0018001014
IED ID IndEnz0018001014
Enzyme Type ID peroxidase001014
Protein Name Putative peroxiredoxin
EC 1.11.1.24
MF1
Thioredoxin reductase
Thioredoxin-dependent peroxiredoxin
allergen Mal f 2
Gene Name
Organism Malassezia furfur (Pityriasis versicolor infection agent) (Pityrosporum furfur)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Basidiomycota Ustilaginomycotina Malasseziomycetes Malasseziales Malasseziaceae Malassezia Malassezia furfur (Pityriasis versicolor infection agent) (Pityrosporum furfur)
Enzyme Sequence MPGDPTATAKGNEIPDTLMGYIPWTPELDSGEVCGIPTTFKTRDEWKGKKVVIVSIPGAYTPICHQQHIPPLVKRVDELKAKGVDAVYVIASNDPFVMAAWGNFNNAKDKVVFATDIDLAFSKALGATIDLSAKHFGERTARYALIIDDNKIVDFASDEGDTGKLQNASIDTILTKV
Enzyme Length 177
Uniprot Accession Number P56577
Absorption
Active Site ACT_SITE 64; /note=Cysteine sulfenic acid (-SOH) intermediate; /evidence=ECO:0000250|UniProtKB:P38013
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O; Xref=Rhea:RHEA:62620, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:50058; EC=1.11.1.24; Evidence={ECO:0000250|UniProtKB:P38013};
DNA Binding
EC Number 1.11.1.24
Enzyme Function FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. {ECO:0000250|UniProtKB:P38013}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Disulfide bond (2); Domain (1); Motif (1)
Keywords Allergen;Antioxidant;Disulfide bond;Oxidoreductase;Peroxidase;Redox-active center
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif MOTIF 175..177; /note=Microbody targeting signal; /evidence=ECO:0000250
Gene Encoded By
Mass 19,193
Kinetics
Metal Binding
Rhea ID RHEA:62620
Cross Reference Brenda