IED ID | IndEnz0018001112 |
Enzyme Type ID | peroxidase001112 |
Protein Name |
Catalase EC 1.11.1.6 |
Gene Name | katA |
Organism | Proteus mirabilis |
Taxonomic Lineage | cellular organisms Bacteria Proteobacteria Gammaproteobacteria Enterobacterales Morganellaceae Proteus Proteus mirabilis |
Enzyme Sequence | MEKKKLTTAAGAPVVDNNNVITAGPRGPMLLQDVWFLEKLAHFDREVIPERRMHAKGSGAFGTFTVTHDITKYTRAKIFSEVGKKTEMFARFSTVAGERGAADAERDIRGFALKFYTEEGNWDMVGNNTPVFYLRDPLKFPDLNHIVKRDPRTNMRNMAYKWDFFSHLPESLHQLTIDMSDRGLPLSYRFVHGFGSHTYSFINKDNERFWVKFHFRCQQGIKNLMDDEAEALVGKDRESSQRDLFEAIERGDYPRWKLQIQIMPEKEASTVPYNPFDLTKVWPHADYPLMDVGYFELNRNPDNYFSDVEQAAFSPANIVPGISFSPDKMLQGRLFSYGDAHRYRLGVNHHQIPVNAPKCPFHNYHRDGAMRVDGNSGNGITYEPNSGGVFQEQPDFKEPPLSIEGAADHWNHREDEDYFSQPRALYELLSDDEHQRMFARIAGELSQASKETQQRQIDLFTKVHPEYGAGVEKAIKVLEGKDAK |
Enzyme Length | 484 |
Uniprot Accession Number | P42321 |
Absorption | |
Active Site | ACT_SITE 54; ACT_SITE 127 |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | CATALYTIC ACTIVITY: Reaction=2 H2O2 = 2 H2O + O2; Xref=Rhea:RHEA:20309, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240; EC=1.11.1.6; Evidence={ECO:0000255|PROSITE-ProRule:PRU10013}; |
DNA Binding | |
EC Number | 1.11.1.6 |
Enzyme Function | FUNCTION: Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Active site (2); Beta strand (18); Chain (1); Helix (21); Metal binding (1); Modified residue (1); Turn (5) |
Keywords | 3D-structure;Cytoplasm;Direct protein sequencing;Heme;Hydrogen peroxide;Iron;Metal-binding;NADP;Oxidation;Oxidoreductase;Peroxidase |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm. |
Modified Residue | MOD_RES 53; /note=Methionine sulfone; /evidence=ECO:0000269|PubMed:7786407 |
Post Translational Modification | |
Signal Peptide | |
Structure 3D | X-ray crystallography (9) |
Cross Reference PDB | 1E93; 1H6N; 1H7K; 1M85; 1MQF; 1NM0; 2CAG; 2CAH; 3HB6; |
Mapped Pubmed ID | 11695923; 14646074; 19394409; 1942042; |
Motif | |
Gene Encoded By | |
Mass | 55,614 |
Kinetics | |
Metal Binding | METAL 337; /note=Iron (heme axial ligand); /evidence=ECO:0000269|PubMed:7791219 |
Rhea ID | RHEA:20309 |
Cross Reference Brenda | 1.11.1.6; |