| IED ID | IndEnz0018001182 |
| Enzyme Type ID | peroxidase001182 |
| Protein Name |
Glutathione peroxidase 7 GPx-7 GSHPx-7 EC 1.11.1.9 CL683 |
| Gene Name | GPX7 GPX6 UNQ469/PRO828 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MVAATVAAAWLLLWAAACAQQEQDFYDFKAVNIRGKLVSLEKYRGSVSLVVNVASECGFTDQHYRALQQLQRDLGPHHFNVLAFPCNQFGQQEPDSNKEIESFARRTYSVSFPMFSKIAVTGTGAHPAFKYLAQTSGKEPTWNFWKYLVAPDGKVVGAWDPTVSVEEVRPQITALVRKLILLKREDL |
| Enzyme Length | 187 |
| Uniprot Accession Number | Q96SL4 |
| Absorption | |
| Active Site | ACT_SITE 57; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O; Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9; |
| DNA Binding | |
| EC Number | 1.11.1.9 |
| Enzyme Function | FUNCTION: It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks. {ECO:0000269|PubMed:22157330}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Beta strand (7); Chain (1); Erroneous translation (1); Helix (7); Sequence conflict (1); Signal peptide (1) |
| Keywords | 3D-structure;Oxidoreductase;Peroxidase;Reference proteome;Secreted;Signal |
| Interact With | Q12797-6; Q8NHQ1; Q9UBL6-2; G5E9A7; O43681; P42858; P61601; Q96HA8; O43765; Q96EQ0; Q7Z699; Q9BQ70; Q9UHD9 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 2P31; |
| Mapped Pubmed ID | 15294905; 16189514; 16713569; 19913121; 20200426; 20628086; 20819778; 21215271; 23123197; 23454490; 23580780; 23828861; 23919619; 24692067; 25416956; 25586538; 26708178; 32719007; 34339889; 34626080; |
| Motif | |
| Gene Encoded By | |
| Mass | 20,996 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:16833 |
| Cross Reference Brenda | 1.11.1.9; |