| IED ID | IndEnz0018001203 |
| Enzyme Type ID | peroxidase001203 |
| Protein Name |
Glutathione peroxidase PcGPx Se-PcGPx EC 1.11.1.9 |
| Gene Name | GPx |
| Organism | Procambarus clarkii (Red swamp crayfish) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Astacidea (true lobsters and crayfishes) Astacoidea (crayfish) Cambaridae Cambarinae Procambarus Procambarus clarkii (Red swamp crayfish) |
| Enzyme Sequence | MSLENGTDVSFEEFRGKVVLVINVATYUGLTVPSYTQMNALAEFYVDQDFVILGFPCNQFEMLEPAANAEIMNGIRYVRPGDGFEPLMTLFEKTEVNGATEDPLFTFLKSACESTYTEFYSSLFYEPIRIGDIQWNFEKFLIGKDGKPYTRYHPDVVDPEALKDDINTLLSA |
| Enzyme Length | 172 |
| Uniprot Accession Number | G9JJU2 |
| Absorption | |
| Active Site | ACT_SITE 28; /evidence=ECO:0000250|UniProtKB:P11352 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O; Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9; Evidence={ECO:0000250|UniProtKB:P22352}; |
| DNA Binding | |
| EC Number | 1.11.1.9 |
| Enzyme Function | FUNCTION: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione (By similarity). May defend against reactive oxygen species that accumulate during the immune response. {ECO:0000250|UniProtKB:P22352, ECO:0000269|PubMed:23567855}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Non-standard residue (1) |
| Keywords | Oxidoreductase;Peroxidase;Selenocysteine |
| Interact With | |
| Induction | INDUCTION: Up-regulated in hepatopancreas following bacterial or viral infection. {ECO:0000269|PubMed:23567855}. |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 19,557 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:16833 |
| Cross Reference Brenda |