Detail Information for IndEnz0018001203
IED ID IndEnz0018001203
Enzyme Type ID peroxidase001203
Protein Name Glutathione peroxidase
PcGPx
Se-PcGPx
EC 1.11.1.9
Gene Name GPx
Organism Procambarus clarkii (Red swamp crayfish)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Astacidea (true lobsters and crayfishes) Astacoidea (crayfish) Cambaridae Cambarinae Procambarus Procambarus clarkii (Red swamp crayfish)
Enzyme Sequence MSLENGTDVSFEEFRGKVVLVINVATYUGLTVPSYTQMNALAEFYVDQDFVILGFPCNQFEMLEPAANAEIMNGIRYVRPGDGFEPLMTLFEKTEVNGATEDPLFTFLKSACESTYTEFYSSLFYEPIRIGDIQWNFEKFLIGKDGKPYTRYHPDVVDPEALKDDINTLLSA
Enzyme Length 172
Uniprot Accession Number G9JJU2
Absorption
Active Site ACT_SITE 28; /evidence=ECO:0000250|UniProtKB:P11352
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O; Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9; Evidence={ECO:0000250|UniProtKB:P22352};
DNA Binding
EC Number 1.11.1.9
Enzyme Function FUNCTION: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione (By similarity). May defend against reactive oxygen species that accumulate during the immune response. {ECO:0000250|UniProtKB:P22352, ECO:0000269|PubMed:23567855}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Non-standard residue (1)
Keywords Oxidoreductase;Peroxidase;Selenocysteine
Interact With
Induction INDUCTION: Up-regulated in hepatopancreas following bacterial or viral infection. {ECO:0000269|PubMed:23567855}.
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 19,557
Kinetics
Metal Binding
Rhea ID RHEA:16833
Cross Reference Brenda