IED ID | IndEnz0018001216 |
Enzyme Type ID | peroxidase001216 |
Protein Name |
Peroxiredoxin Prx EC 1.11.1.27 Glutathione-dependent peroxiredoxin |
Gene Name | |
Organism | Rhizobium etli |
Taxonomic Lineage | cellular organisms Bacteria Proteobacteria Alphaproteobacteria Hyphomicrobiales Rhizobiaceae Rhizobium/Agrobacterium group Rhizobium Rhizobium etli |
Enzyme Sequence | MTMEKQVPIVTFRTRVRDESISGPNPYRWEDKTTDDYFSGKRVILFSLPGAFTPICSTFQLPDFESLYVEFKKNGIDDIYCLSVNDAFVMNAWGKSQGLKNVKLIPDGSGEFTRKMGMLVAKDNLGFGLRSWRYAAVINNGVVEGWFEEEGFGDNCATDPYGVSSPQNILKCLKAPAFV |
Enzyme Length | 179 |
Uniprot Accession Number | O69777 |
Absorption | |
Active Site | ACT_SITE 56; /note=Cysteine sulfenic acid (-SOH) intermediate (for peroxiredoxin activity); /evidence=ECO:0000250|UniProtKB:P44758 |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | CATALYTIC ACTIVITY: Reaction=a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O; Xref=Rhea:RHEA:62632, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.27; Evidence={ECO:0000250|UniProtKB:P44758}; |
DNA Binding | |
EC Number | 1.11.1.27 |
Enzyme Function | FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. {ECO:0000250|UniProtKB:P44758}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Active site (1); Chain (1); Domain (1) |
Keywords | Antioxidant;Oxidoreductase;Peroxidase;Redox-active center |
Interact With | |
Induction | |
Subcellular Location | |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | - |
Motif | |
Gene Encoded By | |
Mass | 20,080 |
Kinetics | |
Metal Binding | |
Rhea ID | RHEA:62632 |
Cross Reference Brenda | 1.11.1.24; |