| IED ID | IndEnz0018001265 |
| Enzyme Type ID | peroxidase001265 |
| Protein Name |
Prostamide/prostaglandin F synthase Prostamide/PG F synthase Prostamide/PGF synthase EC 1.11.1.20 Peroxiredoxin-like 2B |
| Gene Name | Prxl2b Fam213b |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MNVVDLGRVGACVLKHAVTGEAVELRSLWQEKACVVAGLRRFGCMVCRWIAQDLSNLRSILDQHDVRLVGVGPEALGLQEFLDGGYFSGELYLDESKQIYKELGFKRYNSLSILPAALGKPVRDVASKAKAVGIQGNLSGDLLQSGGLLVVSKGGDKVLLHFIQKSPGDYVPQENILQALGISAEVCSSKPPQCDEEVCGR |
| Enzyme Length | 201 |
| Uniprot Accession Number | Q9DB60 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=[thioredoxin]-dithiol + prostaglandin H2 = [thioredoxin]-disulfide + prostaglandin F2alpha; Xref=Rhea:RHEA:28214, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57404, ChEBI:CHEBI:57405; EC=1.11.1.20; Evidence={ECO:0000269|PubMed:18006499}; CATALYTIC ACTIVITY: Reaction=[thioredoxin]-disulfide + prostamide F2alpha = [thioredoxin]-dithiol + prostamide H2; Xref=Rhea:RHEA:26373, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:53081, ChEBI:CHEBI:53082; EC=1.11.1.20; Evidence={ECO:0000269|PubMed:18006499}; |
| DNA Binding | |
| EC Number | 1.11.1.20 |
| Enzyme Function | FUNCTION: Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha). {ECO:0000269|PubMed:18006499}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Modified residue (1); Mutagenesis (2) |
| Keywords | Cytoplasm;Fatty acid biosynthesis;Fatty acid metabolism;Lipid biosynthesis;Lipid metabolism;NADP;Oxidoreductase;Phosphoprotein;Prostaglandin biosynthesis;Prostaglandin metabolism;Reference proteome |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18006499}. |
| Modified Residue | MOD_RES 108; /note=Phosphotyrosine; /evidence=ECO:0000250|UniProtKB:Q8TBF2 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11217851; 12466851; 14610273; 18554416; 21267068; 21554246; 26371508; 33418484; |
| Motif | |
| Gene Encoded By | |
| Mass | 21,670 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:28214; RHEA:26373 |
| Cross Reference Brenda | 1.11.1.20; |