| IED ID | IndEnz0018001290 |
| Enzyme Type ID | peroxidase001290 |
| Protein Name |
Peroxidase skpo-1 EC 1.11.1.7 ShKT and peroxidase domain-containing protein 1 |
| Gene Name | skpo-1 F49E12.1 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MKSLLFSILLIYLIQLVRSEECTDKHIHCFFWSQEGECEVNPRWMKKHCQKACGTCSLTSPTPLTRQQDVPTARTFDDQQDRQFLPSRPSSIPEGCNSVMTVEAETRRIFSSGQLTARFRQQMCAEEQVAPDCSINQCFHKKYRSMDGTCNNLQNPVKGAAFTAFTRLMPAAYDDGFNTLVSASRRNRPNPREVSVFLLSSERSLPGHVNSLLMLFGQFVSHDITSNAAQNFCGCQNSGPMCASIFAPPSDRSRRCIPFTRSFPICGTGQFGRVREQLNMNTAAIDASLIYGSEAITARSLRFAAMLRTSMIGGRMFPPNTNPGSLTAGDGRAILFVGLAALHTSFLRLHNNVAARLQNMNRHWNADRIFQESRKIVGGIVQVITYQEFVPELIGDASKTILGAYNGYNPNVEIGVLNEFAAGAYRLHGMIQETYPLVNSQFQEVNRYRFIDGVNNINHVLNNIDAIYRGMMTVPVRSPQRLTTSVTERLFGGSVDMAAVNIQRGRDHGLRSYNDYRRFCNLRPITSFNDWPEVPDENVRQRIGQLYRTPDDLDFYVGGILEQPAAGSLLGATFACVIGKQFERLRDGDRFYYENPGVFTSPQLAELKRTTLSWVLCQTGDNMVRVGRRAFDIENGSRAVPCSSITGLNLEAWRE |
| Enzyme Length | 655 |
| Uniprot Accession Number | Q20616 |
| Absorption | |
| Active Site | ACT_SITE 222; /note=Proton acceptor; /evidence=ECO:0000255|PROSITE-ProRule:PRU00298 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O; Xref=Rhea:RHEA:56136, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:139520, ChEBI:CHEBI:139521; EC=1.11.1.7; Evidence={ECO:0000250|UniProtKB:Q23490}; |
| DNA Binding | |
| EC Number | 1.11.1.7 |
| Enzyme Function | FUNCTION: Involved in hypodermal immune response against some types of bacterial infection. Probably utilizes H(2)O(2) produced by the NADPH oxidase bli-3. May play a role in cuticule biosynthesis. {ECO:0000269|PubMed:24621828, ECO:0000303|PubMed:24621828}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Disulfide bond (6); Domain (1); Metal binding (1); Signal peptide (1); Site (1) |
| Keywords | Disulfide bond;Heme;Immunity;Innate immunity;Iron;Metal-binding;Oxidoreductase;Peroxidase;Reference proteome;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10778742; 20439774; 21085631; 22267497; 22286215; 22560298; 23800452; 24884423; 25487147; 27506200; 29348603; 33609366; 6593563; |
| Motif | |
| Gene Encoded By | |
| Mass | 73,496 |
| Kinetics | |
| Metal Binding | METAL 428; /note=Iron (heme b axial ligand); /evidence=ECO:0000255|PROSITE-ProRule:PRU00298 |
| Rhea ID | RHEA:56136 |
| Cross Reference Brenda |