Detail Information for IndEnz0018001296
IED ID IndEnz0018001296
Enzyme Type ID peroxidase001296
Protein Name Microsomal glutathione S-transferase 3
Microsomal GST-3
Glutathione peroxidase MGST3
EC 1.11.1.-
Microsomal glutathione S-transferase III
Microsomal GST-III
Gene Name MGST3
Organism Bos taurus (Bovine)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos (oxen cattle) Bos taurus (Bovine)
Enzyme Sequence MAVLSKEYGFVILTGAASFLMVTHLAINVSKARKKYKVEYPTMYSTDPENGHIFNCIQRAHQNTLEVYPPFLFFLAVGGVYHPRIVSGLGLAWIVGRVLYAYGYYTGEPRKRQRGALSFIALIGLMGTTVCSAFQHLGWVRTGLNSGCKSCH
Enzyme Length 152
Uniprot Accession Number Q3T100
Absorption
Active Site
Activity Regulation ACTIVITY REGULATION: Inhibited by MK-886 and leukotriene C4. {ECO:0000250|UniProtKB:D4ADS4}.
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:48620, ChEBI:CHEBI:15377, ChEBI:CHEBI:57450, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:90632; Evidence={ECO:0000250|UniProtKB:O14880};
DNA Binding
EC Number 1.11.1.-
Enzyme Function FUNCTION: Also functions as a glutathione peroxidase. {ECO:0000250}.; FUNCTION: Catalyzes oxydation of hydroxy-fatty acids. May participate to the lipid metabolism. {ECO:0000250|UniProtKB:O14880}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Lipidation (1); Transmembrane (3)
Keywords Endoplasmic reticulum;Lipid metabolism;Lipoprotein;Membrane;Microsome;Oxidoreductase;Palmitate;Reference proteome;Transferase;Transmembrane;Transmembrane helix
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O14880}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14880}. Microsome membrane {ECO:0000250|UniProtKB:O14880}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14880}. Microsome membrane {ECO:0000250|UniProtKB:O14880}; Lipid-anchor {ECO:0000250|UniProtKB:O14880}. Membrane {ECO:0000250|UniProtKB:O14880}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 16,884
Kinetics
Metal Binding
Rhea ID RHEA:48620
Cross Reference Brenda