| IED ID | IndEnz0018001296 |
| Enzyme Type ID | peroxidase001296 |
| Protein Name |
Microsomal glutathione S-transferase 3 Microsomal GST-3 Glutathione peroxidase MGST3 EC 1.11.1.- Microsomal glutathione S-transferase III Microsomal GST-III |
| Gene Name | MGST3 |
| Organism | Bos taurus (Bovine) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos (oxen cattle) Bos taurus (Bovine) |
| Enzyme Sequence | MAVLSKEYGFVILTGAASFLMVTHLAINVSKARKKYKVEYPTMYSTDPENGHIFNCIQRAHQNTLEVYPPFLFFLAVGGVYHPRIVSGLGLAWIVGRVLYAYGYYTGEPRKRQRGALSFIALIGLMGTTVCSAFQHLGWVRTGLNSGCKSCH |
| Enzyme Length | 152 |
| Uniprot Accession Number | Q3T100 |
| Absorption | |
| Active Site | |
| Activity Regulation | ACTIVITY REGULATION: Inhibited by MK-886 and leukotriene C4. {ECO:0000250|UniProtKB:D4ADS4}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:48620, ChEBI:CHEBI:15377, ChEBI:CHEBI:57450, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:90632; Evidence={ECO:0000250|UniProtKB:O14880}; |
| DNA Binding | |
| EC Number | 1.11.1.- |
| Enzyme Function | FUNCTION: Also functions as a glutathione peroxidase. {ECO:0000250}.; FUNCTION: Catalyzes oxydation of hydroxy-fatty acids. May participate to the lipid metabolism. {ECO:0000250|UniProtKB:O14880}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Lipidation (1); Transmembrane (3) |
| Keywords | Endoplasmic reticulum;Lipid metabolism;Lipoprotein;Membrane;Microsome;Oxidoreductase;Palmitate;Reference proteome;Transferase;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O14880}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14880}. Microsome membrane {ECO:0000250|UniProtKB:O14880}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14880}. Microsome membrane {ECO:0000250|UniProtKB:O14880}; Lipid-anchor {ECO:0000250|UniProtKB:O14880}. Membrane {ECO:0000250|UniProtKB:O14880}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 16,884 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:48620 |
| Cross Reference Brenda |